Exposure to RF-EMF Alters Postsynaptic Structure and Hinders Neurite Outgrowth in Developing Hippocampal Neurons of Early Postnatal Mice.

AI: Melanie Research RF Safe Research Library Jan 1, 2021 CONCERN MEDIUM

This animal and primary neuron culture study exposed early postnatal mice to whole-body RF-EMF (SAR 4.0 W/kg) for 5 hours/day from P1 to P28. The authors report reductions in dendritic spine measures (notably mushroom-type spines), decreased glutamate receptor expression in mushroom-type spines, and lower BDNF expression in hippocampal regions. In cultured hippocampal neurons, PSD95 puncta, neurite outgrowth length, and branching were reduced, and exposed mice showed a lower memory index.

Key points

Early postnatal mice and dams were exposed to whole-body RF-EMF at SAR 4.0 W/kg for 5 h/day over 4 weeks (P1–P28).
Total dendritic spine number decreased in the dentate gyrus but was not altered in CA1, while mushroom-type spines decreased in both CA1 and dentate gyrus.
Glutamate receptor expression in mushroom-type dendritic spines was decreased in CA1 and dentate gyrus after exposure.
BDNF expression in CA1 and dentate gyrus was reported to be lower in exposed mice, with decreased BDNF in cultured neurons restricted to the soma.
PSD95 puncta in cultured hippocampal neurons increased over time but were lower at DIV 5, 7, and 9 after exposure.
Neurite outgrowth length and branching were decreased in cultured hippocampal neurons, with no change in soma size.
A decreased memory index was reported in RF-EMF-exposed mice, which the authors link to reduced synaptic density.

Referenced studies & papers

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Source: Open original

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