Electromagnetic field as a possible inhibitor of tumor invasion by declining E-cadherin/N-cadherin switching in triple negative breast cancer.
This in vitro study exposed breast cell lines to a 1 Hz, 100 mT ELF-EMF for 5 days (2 h/day) and assessed migration, invasion, and cadherin expression. The authors report reduced migration and invasion in MDA-MB231 cells versus sham exposure. They also report increased E-cadherin and decreased N-cadherin in MDA-MB231 cells, and increased E-cadherin in MCF10A cells. The abstract suggests ELF-EMF could be explored as part of treatment approaches, but the evidence presented is limited to cell-culture outcomes.
Key points
- The exposure condition was 1 Hz, 100 mT ELF-EMF applied 2 hours per day for five days.
- Migration and invasion were assessed using scratch wound healing and Transwell invasion assays.
- ELF-EMF exposure was reported to reduce migration and invasion of MDA-MB231 cells compared with sham.
- E-cadherin mRNA and protein expression were reported to increase in exposed MDA-MB231 cells versus sham.
- N-cadherin expression was reported to decrease in exposed MDA-MB231 cells versus sham.
- E-cadherin expression was also reported to increase in exposed MCF10A cells compared with sham.
Referenced studies & papers
Relevant papers in OpenMel
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AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
AI-generated summaries may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.
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