Is extremely low frequency pulsed electromagnetic fields (EMF) applicable to gliomas? A literature review of underlying mechanisms and application of extremely low frequency pulsed EMF

PAPER manual 2022 Review Effect: unclear Evidence: Insufficient

Read original paper → DOI: 10.1002/cam4.5112 Evidence Lab

Abstract

Is extremely low frequency pulsed electromagnetic fields (EMF) applicable to gliomas? A literature review of underlying mechanisms and application of extremely low frequency pulsed EMF Huang M, Li P, Chen F, Cai Z, Yang S, Zheng X, Li W. Is extremely low frequency pulsed electromagnetic fields applicable to gliomas? A literature review of the underlying mechanisms and application of extremely low frequency pulsed electromagnetic fields. Cancer Med. 2022 Aug 5. doi: 10.1002/cam4.5112. Abstract Gliomas refer to a group of complicated human brain tumors with a low 5-year survival rate and limited therapeutic options. Extremely low-frequency pulsed electromagnetic field (ELF-PEMF) is a specific magnetic field featuring almost no side effects. However, the application of ELF-PEMF in the treatment of gliomas is rare. This review summarizes five significant underlying mechanisms including calcium ions, autophagy, apoptosis, angiogenesis, and reactive oxygen species, and applications of ELF-PEMF in glioma treatment from a clinical practice perspective. In addition, the prospects of ELF-PEMF in combination with conventional therapy for the treatment of gliomas are reviewed. This review benefits any specialists, especially oncologists, interested in this new therapy because it can help treat patients with gliomas properly. Open access paper: onlinelibrary.wiley.com

AI evidence extraction

At a glance

Study type

Review

Effect direction

unclear

Population

Patients with gliomas (human brain tumors)

Sample size

—

Exposure

ELF therapeutic pulsed electromagnetic field (PEMF)

Evidence strength

Insufficient

Confidence: 66% · Peer-reviewed: yes

Main findings

This literature review summarizes proposed underlying mechanisms (calcium ions, autophagy, apoptosis, angiogenesis, reactive oxygen species) and discusses clinical-practice-oriented applications and prospects of ELF-PEMF, including combination with conventional therapy, for glioma treatment.

Outcomes measured

glioma treatment applications (clinical practice perspective)
mechanistic pathways: calcium ions
mechanistic pathways: autophagy
mechanistic pathways: apoptosis
mechanistic pathways: angiogenesis
mechanistic pathways: reactive oxygen species

Limitations

Narrative/literature review; no primary data reported in abstract
No exposure parameters (e.g., frequency, intensity, treatment duration) provided in abstract
No quantitative synthesis or effect estimates reported in abstract

View raw extracted JSON

{
    "study_type": "review",
    "exposure": {
        "band": "ELF",
        "source": "therapeutic pulsed electromagnetic field (PEMF)",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Patients with gliomas (human brain tumors)",
    "sample_size": null,
    "outcomes": [
        "glioma treatment applications (clinical practice perspective)",
        "mechanistic pathways: calcium ions",
        "mechanistic pathways: autophagy",
        "mechanistic pathways: apoptosis",
        "mechanistic pathways: angiogenesis",
        "mechanistic pathways: reactive oxygen species"
    ],
    "main_findings": "This literature review summarizes proposed underlying mechanisms (calcium ions, autophagy, apoptosis, angiogenesis, reactive oxygen species) and discusses clinical-practice-oriented applications and prospects of ELF-PEMF, including combination with conventional therapy, for glioma treatment.",
    "effect_direction": "unclear",
    "limitations": [
        "Narrative/literature review; no primary data reported in abstract",
        "No exposure parameters (e.g., frequency, intensity, treatment duration) provided in abstract",
        "No quantitative synthesis or effect estimates reported in abstract"
    ],
    "evidence_strength": "insufficient",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "glioma",
        "brain tumor",
        "extremely low frequency",
        "ELF",
        "pulsed electromagnetic field",
        "PEMF",
        "calcium ions",
        "autophagy",
        "apoptosis",
        "angiogenesis",
        "reactive oxygen species",
        "combination therapy"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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