Effect of mobile phone radiation on pentylenetetrazole-induced seizure threshold in mice

PAPER manual Iran J Basic Med Sci 2016 Animal study Effect: harm Evidence: Low

Read original paper → PMID: 27635206 Evidence Lab

Abstract

Objectives: Scientific interest in potential mobile phone impact on human brain and performance has significantly increased in recent years. The present study was designed to evaluate the effects of mobile phone radiation on seizure threshold in mice. Materials and methods: BALB/c male mice were randomly divided into three groups: control, acute, and chronic mobile phone radiation for 30, 60, and 90 min with frequency 900 to 950 MHz and pulse of 217 Hz. The chronic group received 30 days of radiation, while the acute group received only once. The intravenous infusion of pentylenetetrazole (5 mg/ml) was used to induce seizure signs. Results: Although acute mobile radiation did not change seizure threshold, chronic radiation decreased the clonic and tonic seizure thresholds significantly. Conclusion: Our data suggests that the continued and prolonged contact with the mobile phone radiation might increase the risk of seizure attacks and should be limited.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Male BALB/c mice

Sample size

—

Exposure

RF mobile phone · Acute exposure once or chronic exposure for 30 days; exposure sessions were 30, 60, or 90 minutes.

Evidence strength

Low

Confidence: 98% · Peer-reviewed: yes

Main findings

Acute exposure to 900–950 MHz mobile phone radiation did not change seizure threshold. Chronic exposure significantly decreased clonic and tonic seizure thresholds.

Outcomes measured

Pentylenetetrazole-induced clonic seizure threshold
Pentylenetetrazole-induced tonic seizure threshold

Limitations

Animal study; applicability to humans is not established by the abstract.
Sample size was not reported in the abstract.
Specific absorption rate was not reported in the abstract.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": "mobile phone",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "Acute exposure once or chronic exposure for 30 days; exposure sessions were 30, 60, or 90 minutes."
    },
    "population": "Male BALB/c mice",
    "sample_size": null,
    "outcomes": [
        "Pentylenetetrazole-induced clonic seizure threshold",
        "Pentylenetetrazole-induced tonic seizure threshold"
    ],
    "main_findings": "Acute exposure to 900–950 MHz mobile phone radiation did not change seizure threshold. Chronic exposure significantly decreased clonic and tonic seizure thresholds.",
    "effect_direction": "harm",
    "limitations": [
        "Animal study; applicability to humans is not established by the abstract.",
        "Sample size was not reported in the abstract.",
        "Specific absorption rate was not reported in the abstract."
    ],
    "evidence_strength": "low",
    "confidence": 0.979999999999999982236431605997495353221893310546875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "mobile phone radiation",
        "radiofrequency",
        "900–950 MHz",
        "seizure threshold",
        "pentylenetetrazole",
        "BALB/c mice",
        "chronic exposure",
        "acute exposure"
    ],
    "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

Comments

No comments yet.