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Morphometry of red blood cells in sow blood: effects of short-term in vitro exposure to 5G network frequencies

PAPER manual Animal Biotechnology 2026 In vitro study Effect: harm Evidence: Low

Abstract

The effects of 5G radiofrequency electromagnetic radiation (RF-EMR) on complete blood count (CBC) and RBC morphometric parameters in pigs are unknown. Aim of this study was to determine effect of 5G RF-EMR at different frequencies on CBC and RBC morphometry after short-term in vitro exposure of sow blood. Blood samples were taken from 16 sows aged 1 to 2 years. Three ethylenediaminetetraacetic acid (EDTA) tubes per sow were labelled as experimental tubes and three as control tubes. Experimental samples were placed in a Half-cone gigahertz transversal electromagnetic cell and exposed to 5G RF-EMR at 700 MHz, 2500 MHz and 3500 MHz with electric field strength of 10 V/m for 2 hours. CBC was determined using a haematology analyser. RBC morphometric parameters were determined using the computer-assisted program SFORM. The most detrimental effect on sow RBC morphometry was observed after exposure at 700 MHz, resulting in significantly more elongated and irregularly bordered RBCs. These results suggest that in vitro exposure to 5G RF-EMR may impact RBC shape and mechanical properties or integrity, which could affect cell function. This study provides first evidence of frequency-dependent effects of 5G RF-EMR on RBC morphometry and CBC parameters in pigs, offering novel insights for veterinary and translational research.

AI evidence extraction

At a glance
Study type
In vitro study
Effect direction
harm
Population
Blood samples from 16 sows aged 1 to 2 years
Sample size
16
Exposure
RF other · 2 hours; in vitro exposure at 700, 2500, and 3500 MHz; electric field strength 10 V/m
Evidence strength
Low
Confidence: 93% · Peer-reviewed: yes

Main findings

In vitro exposure of sow blood to 5G RF-EMR produced frequency-dependent effects on RBC morphometry and CBC parameters. The strongest reported effect was at 700 MHz, where RBCs were significantly more elongated and had more irregular borders.

Outcomes measured

  • Complete blood count (CBC)
  • Red blood cell (RBC) morphometric parameters
  • RBC shape changes including elongation and irregular borders

Limitations

  • In vitro study
  • Short-term exposure only
  • Animal blood samples rather than human participants
  • Abstract does not report detailed CBC results for each frequency
  • Electric field exposure reported, but SAR not provided
View raw extracted JSON
{
    "study_type": "in_vitro",
    "exposure": {
        "band": "RF",
        "source": "other",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "2 hours; in vitro exposure at 700, 2500, and 3500 MHz; electric field strength 10 V/m"
    },
    "population": "Blood samples from 16 sows aged 1 to 2 years",
    "sample_size": 16,
    "outcomes": [
        "Complete blood count (CBC)",
        "Red blood cell (RBC) morphometric parameters",
        "RBC shape changes including elongation and irregular borders"
    ],
    "main_findings": "In vitro exposure of sow blood to 5G RF-EMR produced frequency-dependent effects on RBC morphometry and CBC parameters. The strongest reported effect was at 700 MHz, where RBCs were significantly more elongated and had more irregular borders.",
    "effect_direction": "harm",
    "limitations": [
        "In vitro study",
        "Short-term exposure only",
        "Animal blood samples rather than human participants",
        "Abstract does not report detailed CBC results for each frequency",
        "Electric field exposure reported, but SAR not provided"
    ],
    "evidence_strength": "low",
    "confidence": 0.93000000000000004884981308350688777863979339599609375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "5G",
        "RF-EMR",
        "radiofrequency",
        "700 MHz",
        "2500 MHz",
        "3500 MHz",
        "red blood cells",
        "RBC morphometry",
        "complete blood count",
        "sow blood",
        "in vitro",
        "animal study"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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