Search for ion-cyclotron resonance in an Na(+)-transport system

Abstract

Colonic tissue from the turtle (Pseudemys scripta) was exposed in a Ussing chamber to simultaneously applied static and time-varying magnetic fields. Transepithelial differences of potential were monitored as frequency of the AC field was varied continuously or in discrete steps from 3 to 770 Hz. Density of the DC field was varied from 10 to 220 microT and that of the AC field from 1 to 20 microT. Short-circuit currents through tissue were monitored for changes that might have been observed under ion-cyclotron resonance (ICR) conditions for each of several ions: H+, Li+, Na+, K+, Ca2+, and Cl-. No discernible changes of transepithelial current were observed. The negative findings are discussed in relation to positive and negative findings that have appeared in the literature.

AI evidence extraction

Main findings

Across AC magnetic-field frequencies from 3 to 770 Hz with simultaneous static (10–220 microT) and time-varying (1–20 microT) magnetic fields, no discernible changes in transepithelial current were observed under tested ion-cyclotron resonance conditions for several ions (H+, Li+, Na+, K+, Ca2+, Cl-).

Outcomes measured

• Transepithelial potential difference
• Short-circuit current (transepithelial current) changes under ion-cyclotron resonance (ICR) conditions for H+, Li+, Na+, K+, Ca2+, Cl-

Limitations

• Sample size not reported in abstract
• Exposure duration not reported in abstract
• Ex vivo tissue preparation (Ussing chamber) may limit generalizability beyond the experimental system

Suggested hubs

• elf-emf (0.78)
  Study tests biological effects of extremely low frequency (3–770 Hz) magnetic fields with a static field component.
• ion-cyclotron-resonance (0.86)
  Explicitly investigates ion-cyclotron resonance conditions for multiple ions.

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    "exposure": {
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        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Colonic tissue from turtle (Pseudemys scripta) in an Ussing chamber",
    "sample_size": null,
    "outcomes": [
        "Transepithelial potential difference",
        "Short-circuit current (transepithelial current) changes under ion-cyclotron resonance (ICR) conditions for H+, Li+, Na+, K+, Ca2+, Cl-"
    ],
    "main_findings": "Across AC magnetic-field frequencies from 3 to 770 Hz with simultaneous static (10–220 microT) and time-varying (1–20 microT) magnetic fields, no discernible changes in transepithelial current were observed under tested ion-cyclotron resonance conditions for several ions (H+, Li+, Na+, K+, Ca2+, Cl-).",
    "effect_direction": "no_effect",
    "limitations": [
        "Sample size not reported in abstract",
        "Exposure duration not reported in abstract",
        "Ex vivo tissue preparation (Ussing chamber) may limit generalizability beyond the experimental system"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "ion-cyclotron resonance",
        "Na+ transport",
        "Ussing chamber",
        "turtle colonic tissue",
        "static magnetic field",
        "time-varying magnetic field",
        "ELF magnetic fields",
        "transepithelial potential",
        "short-circuit current"
    ],
    "suggested_hubs": [
        {
            "slug": "elf-emf",
            "weight": 0.7800000000000000266453525910037569701671600341796875,
            "reason": "Study tests biological effects of extremely low frequency (3–770 Hz) magnetic fields with a static field component."
        },
        {
            "slug": "ion-cyclotron-resonance",
            "weight": 0.85999999999999998667732370449812151491641998291015625,
            "reason": "Explicitly investigates ion-cyclotron resonance conditions for multiple ions."
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}

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