Detection of Low Level Microwave Radiation Induced Deoxyribonucleic Acid Damage Vis-à-vis Genotoxicity in Brain of Fischer Rats.

PAPER pubmed Toxicology international 2013 Animal study Effect: harm Evidence: Low

Read original paper → DOI: 10.4103/0971-6580.111549 PMID: 23833433 Evidence Lab

Abstract

BACKGROUND: Non-ionizing radiofrequency radiation has been increasingly used in industry, commerce, medicine and especially in mobile phone technology and has become a matter of serious concern in present time. OBJECTIVE: The present study was designed to investigate the possible deoxyribonucleic acid (DNA) damaging effects of low-level microwave radiation in brain of Fischer rats. MATERIALS AND METHODS: Experiments were performed on male Fischer rats exposed to microwave radiation for 30 days at three different frequencies: 900, 1800 and 2450 MHz. Animals were divided into 4 groups: Group I (Sham exposed): Animals not exposed to microwave radiation but kept under same conditions as that of other groups, Group II: Animals exposed to microwave radiation at frequency 900 MHz at specific absorption rate (SAR) 5.953 × 10(-4) W/kg, Group III: Animals exposed to 1800 MHz at SAR 5.835 × 10(-4) W/kg and Group IV: Animals exposed to 2450 MHz at SAR 6.672 × 10(-4) W/kg. At the end of the exposure period animals were sacrificed immediately and DNA damage in brain tissue was assessed using alkaline comet assay. RESULTS: In the present study, we demonstrated DNA damaging effects of low level microwave radiation in brain. CONCLUSION: We concluded that low SAR microwave radiation exposure at these frequencies may induce DNA strand breaks in brain tissue.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Male Fischer rats

Sample size

—

Exposure

RF · 30 days

Evidence strength

Low

Confidence: 74% · Peer-reviewed: yes

Main findings

Male Fischer rats exposed for 30 days to microwave radiation at 900, 1800, or 2450 MHz (SARs ~5.835×10^-4 to 6.672×10^-4 W/kg) showed DNA damaging effects in brain tissue assessed by alkaline comet assay, compared with sham-exposed animals.

Outcomes measured

DNA damage in brain tissue (alkaline comet assay)
DNA strand breaks

Limitations

Sample size not reported in abstract.
Exposure source/setup and daily exposure schedule not described in abstract.
Only one endpoint (comet assay in brain) reported in abstract.
Quantitative results/statistics not provided in abstract.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "30 days"
    },
    "population": "Male Fischer rats",
    "sample_size": null,
    "outcomes": [
        "DNA damage in brain tissue (alkaline comet assay)",
        "DNA strand breaks"
    ],
    "main_findings": "Male Fischer rats exposed for 30 days to microwave radiation at 900, 1800, or 2450 MHz (SARs ~5.835×10^-4 to 6.672×10^-4 W/kg) showed DNA damaging effects in brain tissue assessed by alkaline comet assay, compared with sham-exposed animals.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in abstract.",
        "Exposure source/setup and daily exposure schedule not described in abstract.",
        "Only one endpoint (comet assay in brain) reported in abstract.",
        "Quantitative results/statistics not provided in abstract."
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "radiofrequency radiation",
        "microwave radiation",
        "Fischer rats",
        "brain",
        "DNA damage",
        "genotoxicity",
        "comet assay",
        "900 MHz",
        "1800 MHz",
        "2450 MHz",
        "SAR"
    ],
    "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

Comments

No comments yet.