Enzymatic alterations in developing rat brain cells exposed to a low-intensity 16.5 GHz microwave radiation.

PAPER pubmed Electromagnetic biology and medicine 2012 Animal study Effect: harm Evidence: Low

Read original paper → DOI: 10.3109/15368378.2012.700295 PMID: 22897404 Evidence Lab

Abstract

The present study deals with the effects of chronic exposure of low-level microwave radiation on developing rat brain. Starting at 35 days of age, male rats were exposed to 2 h/day for another 35 days to a 16.5-GHz microwave radiation field. After the exposure period, the rats were sacrificed, and brain tissues dissected out and used for biochemical assay. Results showed that exposure to a 16.5-GHz radiation caused significant changes in the activity of protein kinase C as compared to the control group. Furthermore, electron microscopic study revealed an increase in glial cell population. These results confirm that brain cell membrane is an interactive site for electromagnetic field causing an inflammation and possibly tumor promotion.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Male rats (developing rat brain; exposure starting at 35 days of age)

Sample size

—

Exposure

microwave · 16500 MHz · 2 h/day for 35 days (starting at 35 days of age)

Evidence strength

Low

Confidence: 74% · Peer-reviewed: yes

Main findings

Male rats exposed to 16.5 GHz microwave radiation for 2 h/day over 35 days showed significant changes in brain protein kinase C activity compared with controls. Electron microscopy indicated an increase in glial cell population after exposure.

Outcomes measured

Protein kinase C activity in brain tissue
Glial cell population (electron microscopy)

Limitations

Sample size not reported in abstract
Exposure metric (e.g., SAR/power density) not reported in abstract
Only male rats studied
Endpoints are biochemical/ultrastructural; clinical outcomes not assessed

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 16500,
        "sar_wkg": null,
        "duration": "2 h/day for 35 days (starting at 35 days of age)"
    },
    "population": "Male rats (developing rat brain; exposure starting at 35 days of age)",
    "sample_size": null,
    "outcomes": [
        "Protein kinase C activity in brain tissue",
        "Glial cell population (electron microscopy)"
    ],
    "main_findings": "Male rats exposed to 16.5 GHz microwave radiation for 2 h/day over 35 days showed significant changes in brain protein kinase C activity compared with controls. Electron microscopy indicated an increase in glial cell population after exposure.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in abstract",
        "Exposure metric (e.g., SAR/power density) not reported in abstract",
        "Only male rats studied",
        "Endpoints are biochemical/ultrastructural; clinical outcomes not assessed"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "16.5 GHz",
        "microwave radiation",
        "chronic exposure",
        "developing rat brain",
        "protein kinase C",
        "glial cells",
        "electron microscopy",
        "inflammation",
        "tumor promotion"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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