Microwave effects on plasmid DNA.

PAPER pubmed Radiation research 1987 In vitro study Effect: harm Evidence: Low

Read original paper → PMID: 3575652 Evidence Lab

Abstract

The exposure of purified plasmid DNA to microwave radiation at nonthermal levels in the frequency range from 2.00 to 8.75 GHz produces single- and double-strand breaks that are detected by agarose gel electrophoresis. Microwave-induced damage to DNA depends on the presence of small amounts of copper. This effect is dependent upon both the microwave power and the duration of the exposure. Cuprous, but not cupric, ions were able to mimic the effects produced by microwaves on DNA.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

harm

Population

—

Sample size

—

Exposure

microwave

Evidence strength

Low

Confidence: 74% · Peer-reviewed: yes

Main findings

Purified plasmid DNA exposed to nonthermal microwave radiation (2.00–8.75 GHz) showed single- and double-strand breaks detected by agarose gel electrophoresis. DNA damage depended on the presence of small amounts of copper and varied with microwave power and exposure duration; cuprous (not cupric) ions mimicked the microwave effects.

Outcomes measured

DNA single-strand breaks
DNA double-strand breaks

Limitations

In vitro study on purified plasmid DNA (no organism-level outcomes reported).
Specific exposure metrics (e.g., SAR) and detailed dosimetry are not provided in the abstract.
Sample size and experimental replication are not stated in the abstract.

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": null,
    "sample_size": null,
    "outcomes": [
        "DNA single-strand breaks",
        "DNA double-strand breaks"
    ],
    "main_findings": "Purified plasmid DNA exposed to nonthermal microwave radiation (2.00–8.75 GHz) showed single- and double-strand breaks detected by agarose gel electrophoresis. DNA damage depended on the presence of small amounts of copper and varied with microwave power and exposure duration; cuprous (not cupric) ions mimicked the microwave effects.",
    "effect_direction": "harm",
    "limitations": [
        "In vitro study on purified plasmid DNA (no organism-level outcomes reported).",
        "Specific exposure metrics (e.g., SAR) and detailed dosimetry are not provided in the abstract.",
        "Sample size and experimental replication are not stated in the abstract."
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "nonthermal exposure",
        "plasmid DNA",
        "DNA strand breaks",
        "agarose gel electrophoresis",
        "copper",
        "cuprous ions",
        "2.00–8.75 GHz"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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