Rat lymphocytes in cell culture exposed to 2450 MHz (CW) microwave radiation.

PAPER pubmed The Journal of microwave power 1977 In vitro study Effect: no_effect Evidence: Low

Read original paper → DOI: 10.1080/16070658.1977.11689038 PMID: 243542 Evidence Lab

Abstract

Rat lymphocytes were exposed to continuous wave microwave radiation at a frequency of 2450 MHz at intensities of 5, 10 and 20 mW/cm2. The corresponding rates of absorption of energy were determined to be 0.7, 1.4 and 2.8 mW/g. The lymphocytes were exposed for 4, 24 or 44 h either with or without the addition of a mitogen (phytohemagglutinin). The transformation of lymphocytes into lyphoblasts was monitored by the addition of tritiated thymidine. No significant differences (P less than .05) were found in the uptake of tritiated thymidine between exposed and control cultures.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

no_effect

Population

Rat lymphocytes in cell culture

Sample size

—

Exposure

microwave · 2450 MHz · 4, 24, or 44 h

Evidence strength

Low

Confidence: 86% · Peer-reviewed: yes

Main findings

Rat lymphocyte cultures exposed to 2450 MHz continuous-wave microwave radiation at 5, 10, or 20 mW/cm2 (absorption rates 0.7, 1.4, or 2.8 mW/g) for 4, 24, or 44 hours showed no significant differences in tritiated thymidine uptake compared with control cultures, with or without phytohemagglutinin.

Outcomes measured

Lymphocyte transformation into lymphoblasts (tritiated thymidine uptake)

Limitations

Sample size not reported in abstract
Only one biological endpoint reported (tritiated thymidine uptake/lymphocyte transformation)
In vitro cell culture model; generalizability to in vivo outcomes not addressed in abstract

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 2450,
        "sar_wkg": null,
        "duration": "4, 24, or 44 h"
    },
    "population": "Rat lymphocytes in cell culture",
    "sample_size": null,
    "outcomes": [
        "Lymphocyte transformation into lymphoblasts (tritiated thymidine uptake)"
    ],
    "main_findings": "Rat lymphocyte cultures exposed to 2450 MHz continuous-wave microwave radiation at 5, 10, or 20 mW/cm2 (absorption rates 0.7, 1.4, or 2.8 mW/g) for 4, 24, or 44 hours showed no significant differences in tritiated thymidine uptake compared with control cultures, with or without phytohemagglutinin.",
    "effect_direction": "no_effect",
    "limitations": [
        "Sample size not reported in abstract",
        "Only one biological endpoint reported (tritiated thymidine uptake/lymphocyte transformation)",
        "In vitro cell culture model; generalizability to in vivo outcomes not addressed in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.85999999999999998667732370449812151491641998291015625,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "rat lymphocytes",
        "cell culture",
        "microwave radiation",
        "2450 MHz",
        "continuous wave",
        "mW/cm2",
        "energy absorption",
        "phytohemagglutinin",
        "mitogen",
        "tritiated thymidine",
        "lymphocyte transformation"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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