Stability of cefazolin sodium admixtures in plastic bags after thawing by microwave radiation.

PAPER pubmed American journal of hospital pharmacy 1980 Other Effect: unclear Evidence: Insufficient

Read original paper → PMID: 7361792 Evidence Lab

Abstract

The effect on antibiotic stability of thawing, with microwave radiation, cefazolin sodium admixtures frozen in polyvinyl chloride minibags was studied. Two brands of cefazolin sodium (Ancef and Kefzol) were reconstituted and placed in 50-, 100- and 250-ml polyvinyl chloride minibags of 5% dextrose in water or 0.9% sodium chloride. The resulting solutions were assayed for antibiotic stability, using an agar disk diffusion technique, and for pH. The solutions were then stored at -20 degrees C for 48 hours, thawed to room temperature in a microwave oven, and kept at room temperature for four hours, after which they were reassayed for potency and pH. The results indicated that after the freeze-thaw process, the cefazolin sodium minibag admixtures retained at least 90% of their initial antimicrobial activity. The minimal pH changes could not be related to changes in antimicrobial activity, and no color changes could be detected visually. Using a microwave oven can greatly reduce thawing time of antibiotic admixtures. To maintain solution stability and prevent accidents, it is important to calibrate the oven, avoid solution overheating, and observe full precautions in oven operation.

AI evidence extraction

At a glance

Study type

Other

Effect direction

unclear

Population

—

Sample size

—

Exposure

microwave oven

Evidence strength

Insufficient

Confidence: 66% · Peer-reviewed: yes

Main findings

After storage at -20°C for 48 hours and thawing to room temperature in a microwave oven, cefazolin sodium admixtures in polyvinyl chloride minibags retained at least 90% of initial antimicrobial activity after an additional four hours at room temperature. Minimal pH changes were observed and were not related to antimicrobial activity; no visual color changes were detected.

Outcomes measured

cefazolin sodium antimicrobial activity/potency after freeze-thaw and microwave thawing
pH changes
visual color change

View raw extracted JSON

{
    "study_type": "other",
    "exposure": {
        "band": null,
        "source": "microwave oven",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": null,
    "sample_size": null,
    "outcomes": [
        "cefazolin sodium antimicrobial activity/potency after freeze-thaw and microwave thawing",
        "pH changes",
        "visual color change"
    ],
    "main_findings": "After storage at -20°C for 48 hours and thawing to room temperature in a microwave oven, cefazolin sodium admixtures in polyvinyl chloride minibags retained at least 90% of initial antimicrobial activity after an additional four hours at room temperature. Minimal pH changes were observed and were not related to antimicrobial activity; no visual color changes were detected.",
    "effect_direction": "unclear",
    "limitations": [],
    "evidence_strength": "insufficient",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "microwave oven",
        "cefazolin sodium",
        "Ancef",
        "Kefzol",
        "polyvinyl chloride minibags",
        "freeze-thaw",
        "stability",
        "antibiotic admixtures",
        "agar disk diffusion",
        "pH"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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