Microwave radiation-induced calcium ion efflux from human neuroblastoma cells in culture.

PAPER pubmed Bioelectromagnetics 1984 In vitro study Effect: mixed Evidence: Low

Read original paper → DOI: 10.1002/bem.2250050108 PMID: 6712751 Evidence Lab

Abstract

Monolayer cultures of human neuroblastoma cells were exposed to 915-MHz radiation, with or without sinusoidal amplitude modulation (80%) at 16 Hz, at specific absorption rates (SAR) for the culture medium and cells of 0.00, 0.01, 0.05, 0.075, 0.1, 0.5, 0.75, 1.0, 1.5, 2, or 5 mW/g. A significant increase in the efflux of calcium ions (45Ca2+) as compared to unexposed control cultures occurred at two SAR values: 0.05 and 1 mW/g. Increased efflux at 0.05 mW/g was dependent on the presence of amplitude modulation at 16 Hz but at the higher value it was not. These results indicate that human neuroblastoma cells are sensitive to extremely low levels of microwave radiation at certain narrow ranges of SAR.

AI evidence extraction

At a glance

Study type

In vitro study

Effect direction

mixed

Population

human neuroblastoma cells in culture

Sample size

—

Exposure

microwave · 915 MHz · 0.05 W/kg

Evidence strength

Low

Confidence: 50% · Peer-reviewed: yes

Main findings

Exposure to 915 MHz microwave radiation at SAR values of 0.05 and 1 mW/g caused a significant increase in calcium ion efflux from human neuroblastoma cells compared to controls. The increase at 0.05 mW/g required 16 Hz amplitude modulation, while the increase at 1 mW/g did not.

Outcomes measured

calcium ion (45Ca2+) efflux

Limitations

in vitro study, limiting direct extrapolation to humans
only specific SAR values showed effects, indicating narrow sensitivity range
no information on exposure duration or long-term effects

View raw extracted JSON

{
    "study_type": "in_vitro",
    "exposure": {
        "band": "microwave",
        "source": null,
        "frequency_mhz": 915,
        "sar_wkg": 0.05000000000000000277555756156289135105907917022705078125,
        "duration": null
    },
    "population": "human neuroblastoma cells in culture",
    "sample_size": null,
    "outcomes": [
        "calcium ion (45Ca2+) efflux"
    ],
    "main_findings": "Exposure to 915 MHz microwave radiation at SAR values of 0.05 and 1 mW/g caused a significant increase in calcium ion efflux from human neuroblastoma cells compared to controls. The increase at 0.05 mW/g required 16 Hz amplitude modulation, while the increase at 1 mW/g did not.",
    "effect_direction": "mixed",
    "limitations": [
        "in vitro study, limiting direct extrapolation to humans",
        "only specific SAR values showed effects, indicating narrow sensitivity range",
        "no information on exposure duration or long-term effects"
    ],
    "evidence_strength": "low",
    "confidence": 0.5,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "microwave radiation",
        "calcium ion efflux",
        "human neuroblastoma cells",
        "specific absorption rate",
        "amplitude modulation"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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