Mechanisms of senile cataract formation.

PAPER pubmed Ophthalmology 1984 Review Effect: harm Evidence: Insufficient

Read original paper → DOI: 10.1016/s0161-6420(84)34252-x PMID: 6431351 Evidence Lab

Abstract

Research on the mechanisms of lens opacification during the past 20 years has revealed a number of individual, identifiable cataractogenic stresses in man. They include osmotic cataract formation (diabetic, galactosemic and hypoglycemic cataracts), radiation cataracts (X-irradiation, near U.V. radiation and microwave radiation) and in senile cataract the conversion of soluble low molecular weight cytoplasmic proteins to soluble high molecular weight aggregates, insoluble phases, and insoluble membrane-protein matrices. Oxidative stress has emerged as a common denominator of many changes in senile cataract. As we increase our understanding of these mechanisms, we may be able to intervene therapeutically to delay or prevent human cataract formation in man.

AI evidence extraction

At a glance

Study type

Review

Effect direction

harm

Population

man

Sample size

—

Exposure

microwave radiation

Evidence strength

Insufficient

Confidence: 66% · Peer-reviewed: yes

Main findings

The review describes multiple cataractogenic stresses in humans, including radiation cataracts from X-irradiation, near UV radiation, and microwave radiation. It notes that oxidative stress is a common denominator of many changes in senile cataract and describes protein aggregation/insolubilization processes in senile cataract.

Outcomes measured

lens opacification
cataract formation (including radiation cataracts and senile cataract mechanisms)
oxidative stress-related changes in senile cataract

Limitations

Narrative review; no study design details, exposure metrics, or quantitative effect estimates provided in the abstract.
Microwave exposure characteristics (frequency, intensity/SAR, duration) are not specified.
Does not report sample sizes or specific human study results in the abstract.

View raw extracted JSON

{
    "study_type": "review",
    "exposure": {
        "band": null,
        "source": "microwave radiation",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "man",
    "sample_size": null,
    "outcomes": [
        "lens opacification",
        "cataract formation (including radiation cataracts and senile cataract mechanisms)",
        "oxidative stress-related changes in senile cataract"
    ],
    "main_findings": "The review describes multiple cataractogenic stresses in humans, including radiation cataracts from X-irradiation, near UV radiation, and microwave radiation. It notes that oxidative stress is a common denominator of many changes in senile cataract and describes protein aggregation/insolubilization processes in senile cataract.",
    "effect_direction": "harm",
    "limitations": [
        "Narrative review; no study design details, exposure metrics, or quantitative effect estimates provided in the abstract.",
        "Microwave exposure characteristics (frequency, intensity/SAR, duration) are not specified.",
        "Does not report sample sizes or specific human study results in the abstract."
    ],
    "evidence_strength": "insufficient",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "senile cataract",
        "lens opacification",
        "microwave radiation",
        "radiation cataract",
        "ultraviolet radiation",
        "X-irradiation",
        "oxidative stress",
        "protein aggregation"
    ],
    "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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