Cardiac Cell Exposure to Electromagnetic Fields: Focus on Oxdative Stress and Apoptosis.

Abstract

Exposure to electromagnetic fields (EMFs) is a sensitive research topic. Despite extensive research, to date there is no evidence to conclude that exposure to EMFs influences the cardiovascular system. In the present study, we examined whether 915 MHz EMF exposure affects myocardial antioxidative and apoptotic status in vitro and in vivo. No statistically significant difference in the apoptotic cell profile and antioxidant capacity was observed between controls and short-term EMF-exposed mouse cardiomyocytes and H9C2 cardiomyoblasts. Compared with sham-exposed controls, mice subjected to a 915 MHz EMF for 48 h and 72 h had no significant effect on structural tissue integrity and myocardial expression of apoptosis and antioxidant genes. Therefore, these results indicate that short-term exposure to EMF in cardiac cells and tissues did not translate into a significant effect on the myocardial antioxidant defense system and apoptotic cell death.

AI evidence extraction

Main findings

No statistically significant differences were observed in apoptotic cell profile or antioxidant capacity between controls and short-term 915 MHz EMF-exposed mouse cardiomyocytes and H9C2 cardiomyoblasts. In mice exposed to 915 MHz EMF for 48 h or 72 h, there were no significant effects on cardiac tissue integrity or myocardial expression of apoptosis and antioxidant genes versus sham controls.

Outcomes measured

• Apoptotic cell profile
• Antioxidant capacity
• Structural tissue integrity
• Myocardial expression of apoptosis genes
• Myocardial expression of antioxidant genes

Limitations

• Exposure source and dosimetry (e.g., SAR) not reported in abstract
• Sample size not reported in abstract
• Only short-term exposure durations assessed

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": null,
        "frequency_mhz": 915,
        "sar_wkg": null,
        "duration": "short-term; 48 h and 72 h (in vivo); short-term (in vitro)"
    },
    "population": "Mouse cardiomyocytes; H9C2 cardiomyoblasts; mice (cardiac tissue)",
    "sample_size": null,
    "outcomes": [
        "Apoptotic cell profile",
        "Antioxidant capacity",
        "Structural tissue integrity",
        "Myocardial expression of apoptosis genes",
        "Myocardial expression of antioxidant genes"
    ],
    "main_findings": "No statistically significant differences were observed in apoptotic cell profile or antioxidant capacity between controls and short-term 915 MHz EMF-exposed mouse cardiomyocytes and H9C2 cardiomyoblasts. In mice exposed to 915 MHz EMF for 48 h or 72 h, there were no significant effects on cardiac tissue integrity or myocardial expression of apoptosis and antioxidant genes versus sham controls.",
    "effect_direction": "no_effect",
    "limitations": [
        "Exposure source and dosimetry (e.g., SAR) not reported in abstract",
        "Sample size not reported in abstract",
        "Only short-term exposure durations assessed"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "electromagnetic fields",
        "915 MHz",
        "cardiac cells",
        "mouse cardiomyocytes",
        "H9C2 cardiomyoblasts",
        "oxidative stress",
        "antioxidant defense",
        "apoptosis",
        "in vitro",
        "in vivo"
    ],
    "suggested_hubs": []
}

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