Cellular signaling pathways in the nervous system activated by various mechanical and

Abstract

Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli Kazuhito M, Ferguson AR, Aboubacar W, Youngjae R. Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli. Frontiers in Molecular Neuroscience. Vol. 17. 2024. doi: 10.3389/fnmol.2024.1427070. Abstract Mechanical stimuli, such as stretch, shear stress, or compression, activate a range of biomolecular responses through cellular mechanotransduction. In the nervous system, studies on mechanical stress have highlighted key pathophysiological mechanisms underlying traumatic injury and neurodegenerative diseases. However, the biomolecular pathways triggered by mechanical stimuli in the nervous system has not been fully explored, especially compared to other body systems. This gap in knowledge may be due to the wide variety of methods and definitions used in research. Additionally, as mechanical stimulation techniques such as ultrasound and electromagnetic stimulation are increasingly utilized in psychological and neurorehabilitation treatments, it is vital to understand the underlying biological mechanisms in order to develop accurate pathophysiological models and enhance therapeutic interventions. This review aims to summarize the cellular signaling pathways activated by various mechanical and electromagnetic stimuli with a particular focus on the mammalian nervous system. Furthermore, we briefly discuss potential cellular mechanosensors involved in these processes Open access paper: frontiersin.org neuroscience/articles/10.3389/fnmol.2024.1427070

AI evidence extraction

Main findings

This review summarizes cellular signaling pathways in the mammalian nervous system reported to be activated by various mechanical and electromagnetic stimuli, and briefly discusses potential cellular mechanosensors involved.

Outcomes measured

• cellular signaling pathways
• cellular mechanotransduction responses
• potential cellular mechanosensors

Limitations

• No specific electromagnetic exposure parameters (e.g., frequency, intensity/SAR, duration) are provided in the abstract.
• The abstract does not describe specific included study designs, populations, or quantitative results.

{
    "study_type": "review",
    "exposure": {
        "band": null,
        "source": "electromagnetic stimulation",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "mammalian nervous system",
    "sample_size": null,
    "outcomes": [
        "cellular signaling pathways",
        "cellular mechanotransduction responses",
        "potential cellular mechanosensors"
    ],
    "main_findings": "This review summarizes cellular signaling pathways in the mammalian nervous system reported to be activated by various mechanical and electromagnetic stimuli, and briefly discusses potential cellular mechanosensors involved.",
    "effect_direction": "unclear",
    "limitations": [
        "No specific electromagnetic exposure parameters (e.g., frequency, intensity/SAR, duration) are provided in the abstract.",
        "The abstract does not describe specific included study designs, populations, or quantitative results."
    ],
    "evidence_strength": "insufficient",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "mechanotransduction",
        "nervous system",
        "mechanical stimuli",
        "electromagnetic stimulation",
        "ultrasound",
        "neurorehabilitation",
        "cellular signaling pathways",
        "mechanosensors"
    ],
    "suggested_hubs": []
}

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