Pre and postnatal exposure to 900 MHz electromagnetic fields induce inflammation and oxidative stress, and

Abstract

Pre and postnatal exposure to 900 MHz electromagnetic fields induce inflammation and oxidative stress, and alter renin-angiotensin system components Kilic A, Ustunova S, Bulut H, Meral I. Pre and postnatal exposure to 900 MHz electromagnetic fields induce inflammation and oxidative stress, and alter renin-angiotensin system components differently in male and female offsprings. Life Sci. 2023 Mar 28:121627. doi: 10.1016/j.lfs.2023.121627. Abstract Aims: This study was designed to investigate inflammation, oxidative stress and renin-angiotensin system components in brain and kidney tissues of female and male rats prenatally and/or postnatally exposed to 900 MHz electromagnetic field (EMF). It is aimed to evaluate the biological effects of 900 MHz EMF exposure due to the increase in mobile phone use and especially the more widespread use of the GSM 900 system. Main methods: Male and female Wistar albino offsprings were divided into four groups of control, prenatal, postnatal, and prenatal+postnatal exposed to 900 MHz EMF for 1 h/day (23 days during pregnancy for prenatal period, 40 days for postnatal period). The brain and kidney tissues were collected when they reached puberty. Key findings: It was found that the total oxidant status, IL-2, IL-6, and TNF-α levels increased (p < 0.001) and the total antioxidant status levels decreased (p < 0.001) in all three EMF groups comparing to controls in both male and female brain and kidney tissues. The renin- angiotensin system components such as angiotensinogen, renin, angiotensin type 1 and type 2 receptors, and MAS1-like G protein-coupled receptor expression were higher (p < 0.001) in all three EMF exposure groups comparing to controls in both male and female brain and kidney tissues. Although there are some differences of the levels of proinflammatory markers, ROS components and RAS components in brain and kidney tissues between males and females, the common result of all groups was increase in oxidative stress, inflammation markers and angiotensin system components with exposure to 900 MHz EMF. Significance: In conclusion, our study suggested that the 900 MHz EMF can activate brain and kidney renin- angiotensin system, and this activation is maybe related to inflammation and oxidative stress in both male and female offsprings. pubmed.ncbi.nlm.nih.gov

AI evidence extraction

Main findings

Compared with controls, all EMF-exposed groups (prenatal, postnatal, prenatal+postnatal) showed increased total oxidant status and increased IL-2, IL-6, and TNF-α, with decreased total antioxidant status, in both brain and kidney tissues of male and female offspring. Expression of renin-angiotensin system components (angiotensinogen, renin, angiotensin type 1 and type 2 receptors, and MAS1-like receptor) was higher in all EMF exposure groups versus controls in both tissues.

Outcomes measured

• Total oxidant status (TOS)
• Total antioxidant status (TAS)
• IL-2
• IL-6
• TNF-α
• Renin-angiotensin system components (angiotensinogen, renin, AT1 receptor, AT2 receptor, MAS1-like G protein-coupled receptor) expression in brain and kidney

Limitations

• No sample size reported in the provided abstract/metadata
• No SAR or dosimetry details reported in the provided abstract/metadata
• Animal study; generalizability to humans not established in the provided abstract

Suggested hubs

• who-icnirp (0.2)
  RF-EMF bioeffects study relevant to broader RF health evidence base (no specific policy body discussed).

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": "GSM 900 / mobile phone system (context)",
        "frequency_mhz": 900,
        "sar_wkg": null,
        "duration": "Prenatal: 1 h/day for 23 days during pregnancy; Postnatal: 1 h/day for 40 days; Prenatal+postnatal: both periods"
    },
    "population": "Wistar albino rat offsprings (male and female)",
    "sample_size": null,
    "outcomes": [
        "Total oxidant status (TOS)",
        "Total antioxidant status (TAS)",
        "IL-2",
        "IL-6",
        "TNF-α",
        "Renin-angiotensin system components (angiotensinogen, renin, AT1 receptor, AT2 receptor, MAS1-like G protein-coupled receptor) expression in brain and kidney"
    ],
    "main_findings": "Compared with controls, all EMF-exposed groups (prenatal, postnatal, prenatal+postnatal) showed increased total oxidant status and increased IL-2, IL-6, and TNF-α, with decreased total antioxidant status, in both brain and kidney tissues of male and female offspring. Expression of renin-angiotensin system components (angiotensinogen, renin, angiotensin type 1 and type 2 receptors, and MAS1-like receptor) was higher in all EMF exposure groups versus controls in both tissues.",
    "effect_direction": "harm",
    "limitations": [
        "No sample size reported in the provided abstract/metadata",
        "No SAR or dosimetry details reported in the provided abstract/metadata",
        "Animal study; generalizability to humans not established in the provided abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "900 MHz",
        "RF-EMF",
        "GSM 900",
        "prenatal exposure",
        "postnatal exposure",
        "rat",
        "brain",
        "kidney",
        "oxidative stress",
        "inflammation",
        "IL-2",
        "IL-6",
        "TNF-α",
        "renin-angiotensin system",
        "angiotensinogen",
        "renin",
        "AT1 receptor",
        "AT2 receptor",
        "MAS1"
    ],
    "suggested_hubs": [
        {
            "slug": "who-icnirp",
            "weight": 0.200000000000000011102230246251565404236316680908203125,
            "reason": "RF-EMF bioeffects study relevant to broader RF health evidence base (no specific policy body discussed)."
        }
    ]
}

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