Residential proximity to electromagnetic field sources and birth weight: Minimizing residual confounding using multiple imputation and propensity score matching.

Abstract

Studies have suggested that residential exposure to extremely low frequency (50 Hz) electromagnetic fields (ELF-EMF) from high voltage cables, overhead power lines, electricity substations or towers are associated with reduced birth weight and may be associated with adverse birth outcomes or even miscarriages. We previously conducted a study of 140,356 singleton live births between 2004 and 2008 in Northwest England, which suggested that close residential proximity (≤ 50 m) to ELF-EMF sources was associated with reduced average birth weight of 212 g (95%CI: -395 to -29 g) but not with statistically significant increased risks for other adverse perinatal outcomes. However, the cohort was limited by missing data for most potentially confounding variables including maternal smoking during pregnancy, which was only available for a small subgroup, while also residual confounding could not be excluded. This study, using the same cohort, was conducted to minimize the effects of these problems using multiple imputation to address missing data and propensity score matching to minimize residual confounding. Missing data were imputed using multiple imputation using chained equations to generate five datasets. For each dataset 115 exposed women (residing ≤ 50 m from a residential ELF-EMF source) were propensity score matched to 1150 unexposed women. After doubly robust confounder adjustment, close proximity to a residential ELF-EMF source remained associated with a reduction in birth weight of -116 g (95% confidence interval: -224:-7 g). No effect was found for proximity ≤ 100 m compared to women living further away. These results indicate that although the effect size was about half of the effect previously reported, close maternal residential proximity to sources of ELF-EMF remained associated with suboptimal fetal growth.

AI evidence extraction

Main findings

After multiple imputation and propensity score matching with doubly robust adjustment, residential proximity ≤50 m to an ELF-EMF source was associated with lower birth weight (-116 g; 95% CI: -224 to -7 g). No effect was found for proximity ≤100 m compared with living further away.

Outcomes measured

• Birth weight
• Other adverse perinatal outcomes (not specified)

Limitations

• Exposure defined by residential proximity to ELF-EMF sources (not direct field measurements)
• Missing data required multiple imputation
• Only 115 exposed women were included in the propensity score matched analysis (per imputed dataset)

Suggested hubs

• occupational-exposure (0.05)
  Study concerns residential (not occupational) proximity; occupational hub likely not applicable.

{
    "study_type": "cohort",
    "exposure": {
        "band": "ELF",
        "source": "high voltage cables, overhead power lines, electricity substations or towers (residential proximity)",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Singleton live births (mothers) in Northwest England, 2004–2008",
    "sample_size": 140356,
    "outcomes": [
        "Birth weight",
        "Other adverse perinatal outcomes (not specified)"
    ],
    "main_findings": "After multiple imputation and propensity score matching with doubly robust adjustment, residential proximity ≤50 m to an ELF-EMF source was associated with lower birth weight (-116 g; 95% CI: -224 to -7 g). No effect was found for proximity ≤100 m compared with living further away.",
    "effect_direction": "harm",
    "limitations": [
        "Exposure defined by residential proximity to ELF-EMF sources (not direct field measurements)",
        "Missing data required multiple imputation",
        "Only 115 exposed women were included in the propensity score matched analysis (per imputed dataset)"
    ],
    "evidence_strength": "moderate",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "extremely low frequency",
        "ELF-EMF",
        "50 Hz",
        "power lines",
        "substations",
        "residential proximity",
        "birth weight",
        "fetal growth",
        "multiple imputation",
        "propensity score matching",
        "confounding"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.05000000000000000277555756156289135105907917022705078125,
            "reason": "Study concerns residential (not occupational) proximity; occupational hub likely not applicable."
        }
    ]
}

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