Cytotoxic and genotoxic effects of high-frequency electromagnetic fields (GSM 1800 MHz) on immature and mature rats.

PAPER pubmed Ecotoxicology and environmental safety 2012 Animal study Effect: harm Evidence: Low

Read original paper → DOI: 10.1016/j.ecoenv.2012.02.028 PMID: 22405939 Evidence Lab

Abstract

We investigated the cytogenotoxic effects of high frequency electromagnetic fields (HF-EMF) for 45 day and the effect of a recovery period of 15 day after exposure to EMF on bone marrow cells of immature and mature rats. The animals in treatment groups were exposed to 1800 MHz EMF at SAR of 0.37 W/kg and 0.49 W/kg for 2h/day for 45 day. Two recovery groups were kept for a recovery period of 15 day without EMF after exposure to HF-EMF. Two control groups for both immature and mature rats were also included. Significant differences were also observed in chromosome aberrations (CA), micronucleus (MN) frequency, mitotic index (MI) and ratio of polychromatic erythrocytes (PCEs) in all treatment groups. The cytogenotoxic damage was more remarkable in immature rats and, the recovery period did not improve this damage in immature rats. Because much higher and irreversible cytogenotoxic damage was observed in immature rats than in mature rats, further studies are needed to understand effects of EMF on DNA damage and DNA repair, and to determine safe limits for environment and human, especially for children.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Immature and mature rats (bone marrow cells assessed)

Sample size

—

Exposure

RF · 1800 MHz · 2 h/day for 45 days; recovery period 15 days without EMF (in recovery groups)

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

Rats exposed to 1800 MHz EMF for 45 days showed significant differences in chromosome aberrations, micronucleus frequency, mitotic index, and PCE ratio in all treatment groups. Cytogenotoxic damage was more pronounced in immature rats, and a 15-day recovery period did not improve the damage in immature rats.

Outcomes measured

Chromosome aberrations (CA)
Micronucleus (MN) frequency
Mitotic index (MI)
Ratio of polychromatic erythrocytes (PCEs)

Limitations

Sample size not reported in the provided abstract
Exposure source/setup details not described in the provided abstract
Results are reported as 'significant differences' without effect sizes or exact statistics in the provided abstract

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": null,
        "frequency_mhz": 1800,
        "sar_wkg": null,
        "duration": "2 h/day for 45 days; recovery period 15 days without EMF (in recovery groups)"
    },
    "population": "Immature and mature rats (bone marrow cells assessed)",
    "sample_size": null,
    "outcomes": [
        "Chromosome aberrations (CA)",
        "Micronucleus (MN) frequency",
        "Mitotic index (MI)",
        "Ratio of polychromatic erythrocytes (PCEs)"
    ],
    "main_findings": "Rats exposed to 1800 MHz EMF for 45 days showed significant differences in chromosome aberrations, micronucleus frequency, mitotic index, and PCE ratio in all treatment groups. Cytogenotoxic damage was more pronounced in immature rats, and a 15-day recovery period did not improve the damage in immature rats.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported in the provided abstract",
        "Exposure source/setup details not described in the provided abstract",
        "Results are reported as 'significant differences' without effect sizes or exact statistics in the provided abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "1800 MHz",
        "GSM",
        "RF-EMF",
        "SAR",
        "rat",
        "bone marrow",
        "cytotoxicity",
        "genotoxicity",
        "chromosome aberrations",
        "micronucleus",
        "mitotic index",
        "polychromatic erythrocytes",
        "recovery period"
    ],
    "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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