Effect of radiation emitted from mobile phone on bone marrow haematopoietic stem cell in mice

Abstract

Effect of radiation emitted from mobile phone on bone marrow haematopoietic stem cell in mice Yinhui P, Hui G, Mingzhu Z, Xiaoping W, Jian S, Fangyuan Z, Yufang Z, Yajing Y. Effect of radiation emitted from mobile phone on bone marrow haematopoietic stem cell in mice. Published online: 14 Jun 2023. doi: 10.1080/10420150.2023.2222331 Abstract The present research aims to explore the potential impact of mobile phone radiation on bone marrow haematopoietic stem cell in mice. 160 male BALB/C mice aged 3–4 weeks were randomly distributed into 4 groups as blank control, control, TD-SCDMA and LTE-Advanced respectively, with 40 mice in each group. Mice were designed to receive cell phone radiation for 2–8 weeks. 10 mice in each group were taken out for examinations given radiation exposure periods were 2, 4, 6 and 8 weeks respectively. Then terminal deoxynuclotidyl transferase-mediated dUTP Nick-end labelling technique was conducted to detect the apoptosis of stem cell, and morphological method was carried out for the examination of micronucleus and subpopulations of bone marrow haematopoietic stem cell, while enzyme immune technique was performed to analyse the subsets of T lymphocyte. As a result, no statistical differences were discovered on issues of apoptosis and micronucleus during the entire experimental period in the 2 sham radiation control groups. Notwithstanding similar results were seen in TD-SCDMA and LTE-Advanced groups after exposed to radiation for 2 or 4 weeks, apoptosis began to be enhanced and micronucleus to be increased given the mice experience longer exposure as 6 or 8 weeks. There were virtually negligible effects on subpopulations of stem cell, as well as on subsets of T lymphocyte of peripheral blood during the entire experimental period in the 4 groups. It could be concluded that long-term radiation from cell phone could induce apoptosis of haematopoietic stem cell in mice; moreover, it seems to stimulate the formation of micronucleus, yet with even negligible effect on the proportions of stem cell subpopulations and peripheral blood T lymphocyte subsets. tandfonline.com

AI evidence extraction

Main findings

In TD-SCDMA and LTE-Advanced exposure groups, apoptosis and micronucleus outcomes were similar to controls after 2 or 4 weeks, but apoptosis increased and micronucleus increased after 6 or 8 weeks of exposure. Stem cell subpopulations and peripheral blood T lymphocyte subsets showed virtually negligible effects across all groups during the experimental period.

Outcomes measured

• Apoptosis of bone marrow haematopoietic stem cells (TUNEL)
• Micronucleus formation in bone marrow (morphological method)
• Subpopulations of bone marrow haematopoietic stem cells
• Peripheral blood T lymphocyte subsets (enzyme immune technique)

Limitations

• No RF exposure parameters reported in abstract (e.g., frequency, power, SAR).
• Exposure setup details not described in abstract (e.g., distance to phone, duty cycle, shielding).
• Results described without quantitative effect sizes or p-values in abstract.
• Animal model; generalizability to humans not addressed in abstract.

Suggested hubs

• mobile-phones-rf (0.9)
  Study tests radiation emitted from mobile phones (TD-SCDMA, LTE-Advanced) in mice.

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    "exposure": {
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        "source": "mobile phone",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "2–8 weeks"
    },
    "population": "Male BALB/C mice (3–4 weeks old)",
    "sample_size": 160,
    "outcomes": [
        "Apoptosis of bone marrow haematopoietic stem cells (TUNEL)",
        "Micronucleus formation in bone marrow (morphological method)",
        "Subpopulations of bone marrow haematopoietic stem cells",
        "Peripheral blood T lymphocyte subsets (enzyme immune technique)"
    ],
    "main_findings": "In TD-SCDMA and LTE-Advanced exposure groups, apoptosis and micronucleus outcomes were similar to controls after 2 or 4 weeks, but apoptosis increased and micronucleus increased after 6 or 8 weeks of exposure. Stem cell subpopulations and peripheral blood T lymphocyte subsets showed virtually negligible effects across all groups during the experimental period.",
    "effect_direction": "harm",
    "limitations": [
        "No RF exposure parameters reported in abstract (e.g., frequency, power, SAR).",
        "Exposure setup details not described in abstract (e.g., distance to phone, duty cycle, shielding).",
        "Results described without quantitative effect sizes or p-values in abstract.",
        "Animal model; generalizability to humans not addressed in abstract."
    ],
    "evidence_strength": "low",
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    "peer_reviewed_likely": "yes",
    "keywords": [
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        "RF exposure",
        "TD-SCDMA",
        "LTE-Advanced",
        "bone marrow",
        "haematopoietic stem cell",
        "apoptosis",
        "micronucleus",
        "mice",
        "T lymphocyte subsets"
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