The influence of electromagnetic field irradiated by high-voltage transmission lines on properties of cells.

PAPER pubmed Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2005 Animal study Effect: harm Evidence: Very low

Read original paper → DOI: 10.1109/iembs.2005.1617104 PMID: 17282873 Evidence Lab

Abstract

The influence of low-frequency electromagnetic field irradiating by high-voltage transmission lines on signal transduction of cell in spleen cells of the rates have been studied by molecular-biology techniques. The spleen cells are extracted from skilled rates, which are exposed in the electromagnetic field of high-voltage transmission lines with 4000 V/m and 0.09-0.1 G about 400 days. The quantity or level of phosphorylation of signal transducer and activator of transcription (STAT3) in JAK-STAT signal transduction pathway of spleen cells, which are stimulated and unstimulated by IL-2, respectively, are detected by the immunoblotting and immunobiochemistry. The results show that the expression of phospho-STAT3 in spleen cell stimulated by IL-2 differ not from that in the unstimulated cell. The former is significantly large than the latter. This shows that signal transduction of cell is affected by this electromagnetic field. The spectra of infrared absorption for the general G-proteins participating this signal transduction of cell for the controlled and exposed groups, which are measured by Nicoletic FT-IR 670 spectrometer, are obviously different both the intensity and frequency of these peaks. This shows that molecular structure or conformation of the proteins changes under influence of the electromagnetic field of high-voltage transmission lines, which results just to above changes of the JAK-STAT signal transduction of cell.

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

harm

Population

Rat spleen cells (from rats exposed to fields from high-voltage transmission lines)

Sample size

—

Exposure

ELF high-voltage transmission lines · about 400 days

Evidence strength

Very low

Confidence: 66% · Peer-reviewed: yes

Main findings

Rats were exposed to fields from high-voltage transmission lines (4000 V/m and 0.09–0.1 G) for about 400 days. The authors report differences in phospho-STAT3 expression and that FT-IR spectra of G-proteins differed between exposed and control groups, interpreted as EMF-related changes in protein conformation and JAK-STAT signaling.

Outcomes measured

Phosphorylation level/expression of STAT3 (phospho-STAT3) in JAK-STAT pathway (IL-2 stimulated vs unstimulated)
Infrared absorption spectra of general G-proteins (protein structure/conformation indicators) measured by FT-IR

Limitations

Sample size not reported
Exposure frequency not reported
Details of control/sham conditions not described in abstract
Outcome reporting is unclear/possibly internally inconsistent regarding IL-2 stimulated vs unstimulated comparisons
Animal/cell findings may not generalize to humans

Suggested hubs

occupational-exposure (0.55)
Exposure source is high-voltage transmission lines (power-line ELF fields), relevant to power/utility environments.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "ELF",
        "source": "high-voltage transmission lines",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "about 400 days"
    },
    "population": "Rat spleen cells (from rats exposed to fields from high-voltage transmission lines)",
    "sample_size": null,
    "outcomes": [
        "Phosphorylation level/expression of STAT3 (phospho-STAT3) in JAK-STAT pathway (IL-2 stimulated vs unstimulated)",
        "Infrared absorption spectra of general G-proteins (protein structure/conformation indicators) measured by FT-IR"
    ],
    "main_findings": "Rats were exposed to fields from high-voltage transmission lines (4000 V/m and 0.09–0.1 G) for about 400 days. The authors report differences in phospho-STAT3 expression and that FT-IR spectra of G-proteins differed between exposed and control groups, interpreted as EMF-related changes in protein conformation and JAK-STAT signaling.",
    "effect_direction": "harm",
    "limitations": [
        "Sample size not reported",
        "Exposure frequency not reported",
        "Details of control/sham conditions not described in abstract",
        "Outcome reporting is unclear/possibly internally inconsistent regarding IL-2 stimulated vs unstimulated comparisons",
        "Animal/cell findings may not generalize to humans"
    ],
    "evidence_strength": "very_low",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "extremely low frequency",
        "ELF",
        "high-voltage transmission lines",
        "electric field",
        "magnetic field",
        "rat",
        "spleen cells",
        "signal transduction",
        "JAK-STAT",
        "STAT3 phosphorylation",
        "IL-2",
        "G-proteins",
        "FT-IR"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.5500000000000000444089209850062616169452667236328125,
            "reason": "Exposure source is high-voltage transmission lines (power-line ELF fields), relevant to power/utility environments."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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