Evaluation of mulitprobe radiofrequency technology in a porcine model.

Abstract

OBJECTIVE: We evaluated two new radiofrequency devices in an in vivo porcine model. MATERIALS AND METHODS: Multiprobe radiofrequency ablation (RFA) was used in a porcine model with an impedance-based algorithm in one experiment and clustered probes with and without switcher controllers in another; a Pringle maneuver was used with half of the ablations. RESULTS: The impedance experiment included 13 ablations, with a mean length of 7.0 cm and width of 2.9 cm (95% CI) and an average time of 596 s. Ablation volumes were significantly larger (54.1+/-11.7 cc(3) vs 34.9+/-4.8 cc(3), p<0.05) and ablation times were significantly shorter (359 s vs 834 s, p<0.05) for the Pringle group compared with the No Pringle group, respectively. The switcher controller experiment included 34 RFAs. Diameter (mm) (51.4 vs 40.3, p<0.0001), surface area (cm(2)) (22.4 vs 16.0, p<0.0002), and volume (cc) (66.1 vs 36.9, p<0.0001) were significantly larger for the combination probes with switcher controller compared with clustered probes, respectively. Ablation volumes for the Pringle vs No Pringle groups in the combination probes were 68.0 cc vs 64.3 cc and for the clustered probes 40.1 cc vs. 33.7 cc, respectively. CONCLUSION: Multiprobe ablations using RFA are promising technologies that need further study to evaluate their clinical utility.

AI evidence extraction

Main findings

In a porcine in vivo model, Pringle maneuver was associated with significantly larger ablation volumes and shorter ablation times in the impedance-based experiment. In the switcher controller experiment, combination probes with a switcher controller produced significantly larger ablation diameter, surface area, and volume than clustered probes.

Outcomes measured

• Ablation size (length, width, diameter, surface area, volume)
• Ablation time

Limitations

• No RF exposure parameters reported (e.g., frequency, SAR)
• Animal model; clinical utility not established
• Sample size not clearly stated (number of animals not provided; only number of ablations reported)

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": "radiofrequency ablation device",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Porcine model (in vivo)",
    "sample_size": null,
    "outcomes": [
        "Ablation size (length, width, diameter, surface area, volume)",
        "Ablation time"
    ],
    "main_findings": "In a porcine in vivo model, Pringle maneuver was associated with significantly larger ablation volumes and shorter ablation times in the impedance-based experiment. In the switcher controller experiment, combination probes with a switcher controller produced significantly larger ablation diameter, surface area, and volume than clustered probes.",
    "effect_direction": "unclear",
    "limitations": [
        "No RF exposure parameters reported (e.g., frequency, SAR)",
        "Animal model; clinical utility not established",
        "Sample size not clearly stated (number of animals not provided; only number of ablations reported)"
    ],
    "evidence_strength": "insufficient",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "radiofrequency ablation",
        "multiprobe",
        "porcine model",
        "Pringle maneuver",
        "switcher controller",
        "impedance-based algorithm"
    ],
    "suggested_hubs": []
}

Comments

Log in to comment.

No comments yet.