Exposure to a 0.9-GHz electromagnetic field on postnatal days 21-45 may trigger the renin-angiotensin
Abstract
Exposure to a 0.9-GHz electromagnetic field on postnatal days 21-45 may trigger the renin-angiotensin system in male rat: a histological and biochemical study Keleş Aİ, Kaya H, Keleş G, Erol HS, Mercantepe T, Odaci E. Exposure to a 0.9-GHz electromagnetic field on postnatal days 21-45 may trigger the renin-angiotensin system in male rat: a histological and biochemical study. J Mol Histol. 2024 Dec 4;56(1):22. doi: 10.1007/s10735-024-10317-y. Abstract The aim of this study was to examine the relationship between the renin-angiotensin system (RAS) and histological and biochemical changes occurring in the kidney tissue of male rats exposed to a 0.9 GHz electromagnetic field (EMF). Twelve male rats aged 21 days were randomly assigned to control (C-Gr) and EMF (EMF-Gr) groups. No procedure was performed on C-Gr, while the EMF-Gr rats were exposed to a 0.9 GHz EMF on postnatal days 21-45 (one hour a day for 25 days). Tissues were removed at the end of the experiment and evaluated using biochemical, and histopathological methods. Increased kidney tissue volume and weight and total body weight were determined in the group exposed to EMF. Lipid peroxidation, glutathione, catalase, and superoxide dismutase also increased in the kidney tissue of the EMF-Gr rats. Histopathological evaluation revealed cortical/medullary bleeding/obstruction and widespread fibrosis, dilatation, vacuolization, and degeneration in distal and proximal tubules, decreased and atypical parietal cells, and degeneration in epithelial cells. Additionally, dilated and degenerated glomeruli in the Malpighian body, Bowman's membrane degeneration and degeneration in the vascular pole, podocyte, pedicel and mesangial cells were also observed. As a result of exposure to EMF, oxidative stress, tissue volume and weight increased, and histopathological changes caused the formation of a pathway that triggers RAS in kidney tissues. In conclusion, long-term exposure to 0.9 GHz EMF can activate the renin-angiotensin system in the rat kidney, and we think that such activation may be associated with structural, histopathological, and biochemical changes occurring in renal tissue. pubmed.ncbi.nlm.nih.gov
AI evidence extraction
Main findings
In this rat study, exposure to a 0.9 GHz EMF for 1 hour/day over postnatal days 21–45 was associated with increased kidney tissue volume and weight and increased total body weight. The exposed group showed increases in lipid peroxidation, glutathione, catalase, and superoxide dismutase in kidney tissue, along with multiple histopathological alterations (e.g., bleeding/obstruction, fibrosis, tubular degeneration, and glomerular changes). The authors conclude that these changes formed a pathway that triggers/activates the renin-angiotensin system in the rat kidney.
Outcomes measured
- Kidney tissue volume and weight
- Total body weight
- Oxidative stress/antioxidant markers (lipid peroxidation, glutathione, catalase, superoxide dismutase)
- Kidney histopathology (bleeding/obstruction, fibrosis, tubular and glomerular changes)
- Renin-angiotensin system (RAS) activation (inferred pathway triggering)
Limitations
- Small sample size (12 rats total).
- Animal study; findings may not generalize to humans.
- No SAR or dosimetry details reported in the abstract.
- Control group described as receiving no procedure; sham exposure conditions are not described in the abstract.
View raw extracted JSON
{
"publication_year": 2024,
"study_type": "animal",
"exposure": {
"band": "RF",
"source": null,
"frequency_mhz": 900,
"sar_wkg": null,
"duration": "1 hour/day for 25 days (postnatal days 21–45)"
},
"population": "Male rats (21 days old at start)",
"sample_size": 12,
"outcomes": [
"Kidney tissue volume and weight",
"Total body weight",
"Oxidative stress/antioxidant markers (lipid peroxidation, glutathione, catalase, superoxide dismutase)",
"Kidney histopathology (bleeding/obstruction, fibrosis, tubular and glomerular changes)",
"Renin-angiotensin system (RAS) activation (inferred pathway triggering)"
],
"main_findings": "In this rat study, exposure to a 0.9 GHz EMF for 1 hour/day over postnatal days 21–45 was associated with increased kidney tissue volume and weight and increased total body weight. The exposed group showed increases in lipid peroxidation, glutathione, catalase, and superoxide dismutase in kidney tissue, along with multiple histopathological alterations (e.g., bleeding/obstruction, fibrosis, tubular degeneration, and glomerular changes). The authors conclude that these changes formed a pathway that triggers/activates the renin-angiotensin system in the rat kidney.",
"effect_direction": "harm",
"limitations": [
"Small sample size (12 rats total).",
"Animal study; findings may not generalize to humans.",
"No SAR or dosimetry details reported in the abstract.",
"Control group described as receiving no procedure; sham exposure conditions are not described in the abstract."
],
"evidence_strength": "low",
"confidence": 0.7800000000000000266453525910037569701671600341796875,
"peer_reviewed_likely": "yes",
"stance": "concern",
"stance_confidence": 0.8000000000000000444089209850062616169452667236328125,
"summary": "This animal study examined kidney histological and biochemical changes and their relationship to the renin-angiotensin system (RAS) after 0.9 GHz EMF exposure. Twelve male rats were assigned to control or EMF exposure (1 hour/day for 25 days, postnatal days 21–45). The exposed group showed increased kidney volume/weight, increased oxidative stress-related markers, and extensive renal histopathological alterations, which the authors interpret as triggering/activating RAS in kidney tissue.",
"key_points": [
"Twelve 21-day-old male rats were randomized to control or 0.9 GHz EMF exposure groups.",
"Exposure occurred 1 hour per day for 25 days (postnatal days 21–45).",
"The EMF-exposed group had increased kidney tissue volume and weight and increased total body weight.",
"Kidney tissue lipid peroxidation, glutathione, catalase, and superoxide dismutase were reported to increase after exposure.",
"Histopathology in exposed rats included bleeding/obstruction, widespread fibrosis, and tubular dilatation, vacuolization, and degeneration.",
"Glomerular and Bowman’s membrane degeneration and changes in podocyte/mesangial-related structures were also described.",
"Authors conclude that long-term 0.9 GHz EMF exposure can activate the renin-angiotensin system in rat kidney."
],
"categories": [
"Animal Studies",
"Radiofrequency (RF)",
"Kidney & Renal Effects",
"Oxidative Stress",
"Histopathology"
],
"tags": [
"900 MHz",
"Radiofrequency Exposure",
"Rat Study",
"Kidney Tissue",
"Renin-Angiotensin System",
"Oxidative Stress",
"Lipid Peroxidation",
"Glutathione",
"Catalase",
"Superoxide Dismutase",
"Fibrosis",
"Tubular Degeneration",
"Glomerular Changes"
],
"keywords": [
"0.9 GHz",
"EMF",
"kidney",
"renin-angiotensin system",
"oxidative stress",
"histopathology",
"rat"
],
"suggested_hubs": [],
"social": {
"tweet": "Rat study (n=12) reports that 0.9 GHz EMF exposure (1 h/day for 25 days, postnatal days 21–45) was associated with increased kidney weight/volume, oxidative stress marker changes, and renal histopathology; authors suggest activation of the renin-angiotensin system.",
"facebook": "A small rat study examined kidney effects after 0.9 GHz EMF exposure (1 hour/day for 25 days during postnatal days 21–45). The exposed group showed increased kidney weight/volume, changes in oxidative stress-related markers, and multiple renal histopathological alterations; the authors interpret these findings as triggering/activating the renin-angiotensin system in kidney tissue.",
"linkedin": "In a 2024 Journal of Molecular Histology rat study (n=12), 0.9 GHz EMF exposure (1 h/day for 25 days, postnatal days 21–45) was associated with increased kidney weight/volume, altered oxidative stress-related markers, and extensive renal histopathological changes; authors conclude these changes may activate the renin-angiotensin system in the rat kidney."
}
}
AI can be wrong. Always verify against the paper.
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