Active matter as the underpinning agency for extraordinary sensitivity of biological membranes to electric fields

Abstract

Category: Biophysics Tags: biological membranes, electric fields, sensitivity, nonequilibrium, active matter, electromechanics, statistical mechanics DOI: 10.1073/pnas.2427255122 URL: pubmed.ncbi.nlm.nih.gov Overview The interaction of electric fields with biological cells plays a critical role in various physiological processes. Traditionally, thermal electrical noise in the cellular environment is considered the lowest threshold for detection of electrical signals. However, recent experimental evidence demonstrates that some cells and organisms can sense electric fields much weaker than this thermal noise limit calculated using equilibrium considerations. Findings - Novel Model: The study proposes a nonequilibrium statistical mechanics model for active electromechanical membranes. - Role of Activity: The research hypothesizes that activity in biological membranes, often driven by protein machinery utilizing external energy, lets these membranes detect electric fields far weaker than expected under equilibrium statistical mechanics. - Supporting Evidence: The proposed model successfully reproduces experimental results by adjusting the level of activity in membranes. - Significance: By resolving the paradox between theoretical predictions and experimental observations, this study opens new potential for understanding physiological and pathological processes, and for harnessing this extraordinary sensitivity in diagnostics and therapeutics. Conclusion The research highlights that the sensitivity of biological membranes to electric fields can be drastically enhanced through active mechanisms. This means that membranes (and thus, cells) can detect and respond to electrical signals far below the traditional thermal noise floor—establishing a direct connection between weak electromagnetic fields and possible biological responses. The work also suggests future avenues of research, including modeling electromechanical coupling like flexoelectricity and studying how active noise in membrane polarization may affect biological phenomena. This could have broad implications for biotechnology and medicine, especially regarding the safety and effects of electromagnetic field exposure.

AI evidence extraction

Main findings

The paper proposes a nonequilibrium statistical mechanics model of active electromechanical membranes to explain experimental observations that some cells/organisms can sense electric fields weaker than the equilibrium thermal noise limit. The model is reported to reproduce experimental results by tuning the level of membrane activity, suggesting active processes can enhance membrane sensitivity to weak electric fields.

Outcomes measured

• Sensitivity/detection threshold of biological membranes/cells to weak electric fields (below thermal noise limit)
• Mechanistic explanation via nonequilibrium/active electromechanical membrane model

Limitations

• No specific exposure parameters (frequency, intensity, SAR, duration) are provided in the abstract.
• The abstract describes a proposed model and its ability to reproduce prior experimental results, but does not detail the underlying experimental datasets or methods.
• No specific health endpoints or adverse outcomes are reported in the abstract.

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    },
    "population": null,
    "sample_size": null,
    "outcomes": [
        "Sensitivity/detection threshold of biological membranes/cells to weak electric fields (below thermal noise limit)",
        "Mechanistic explanation via nonequilibrium/active electromechanical membrane model"
    ],
    "main_findings": "The paper proposes a nonequilibrium statistical mechanics model of active electromechanical membranes to explain experimental observations that some cells/organisms can sense electric fields weaker than the equilibrium thermal noise limit. The model is reported to reproduce experimental results by tuning the level of membrane activity, suggesting active processes can enhance membrane sensitivity to weak electric fields.",
    "effect_direction": "unclear",
    "limitations": [
        "No specific exposure parameters (frequency, intensity, SAR, duration) are provided in the abstract.",
        "The abstract describes a proposed model and its ability to reproduce prior experimental results, but does not detail the underlying experimental datasets or methods.",
        "No specific health endpoints or adverse outcomes are reported in the abstract."
    ],
    "evidence_strength": "insufficient",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "biological membranes",
        "electric fields",
        "sensitivity",
        "nonequilibrium",
        "active matter",
        "electromechanics",
        "statistical mechanics",
        "thermal noise limit",
        "active mechanisms",
        "flexoelectricity"
    ],
    "suggested_hubs": []
}

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