The biological effects of terahertz wave radiation-induced injury on neural stem cells

Abstract

The biological effects of terahertz wave radiation-induced injury on neural stem cells Wang Y, Xiong Y, Chen M, Liu F, He H, Ma Q, Gao P, Xiang G, Zhang L. The biological effects of terahertz wave radiation-induced injury on neural stem cells. iScience. 2023 Jul 18;26(10):107418. doi: 10.1016/j.isci.2023.107418. Abstract Terahertz (THz) is an electromagnetic wave with a radiation wavelength range of 30-3000 μm and a frequency of 0.1-10 THz. With the development of new THz sources and devices, THz has been widely applied in various fields. However, there are few studies on biological effects of THz irradiation on the human neural stem cells (hNSCs) and mouse neural stem cells (mNSCs), which need to be further studied. We studied the biological effects of THz radiation on hNSCs and mNSCs. The effects of THz irradiation time and average output power on the proliferation, apoptosis, and DNA damage of NSCs were analyzed by flow cytometry and immunofluorescence. The results showed that the proliferation and apoptosis of NSCs were dose-dependently affected by THz irradiation time and average output power. The proliferation of hNSCs was more vulnerable to damage and apoptosis was more serious under the same terahertz irradiation conditions compared to those of mNSCs. Open access paper: cell.com

AI evidence extraction

Main findings

THz irradiation time and average output power dose-dependently affected neural stem cell proliferation and apoptosis. Under the same irradiation conditions, hNSC proliferation was reported as more vulnerable to damage and apoptosis was more severe compared with mNSCs.

Outcomes measured

• Cell proliferation
• Apoptosis
• DNA damage

Limitations

• No specific THz frequency within 0.1–10 THz reported
• No exposure metrics such as SAR or field strength reported
• Sample size not reported
• In vitro findings; generalizability to in vivo/humans not addressed in abstract

Suggested hubs

• 5g-policy (0.15)
  Terahertz/mmWave-adjacent high-frequency EMF topic; not explicitly 5G but relevant to emerging high-frequency technologies.

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    "exposure": {
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        "source": null,
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "varied irradiation time (dose-dependent effects reported)"
    },
    "population": "Human neural stem cells (hNSCs) and mouse neural stem cells (mNSCs)",
    "sample_size": null,
    "outcomes": [
        "Cell proliferation",
        "Apoptosis",
        "DNA damage"
    ],
    "main_findings": "THz irradiation time and average output power dose-dependently affected neural stem cell proliferation and apoptosis. Under the same irradiation conditions, hNSC proliferation was reported as more vulnerable to damage and apoptosis was more severe compared with mNSCs.",
    "effect_direction": "harm",
    "limitations": [
        "No specific THz frequency within 0.1–10 THz reported",
        "No exposure metrics such as SAR or field strength reported",
        "Sample size not reported",
        "In vitro findings; generalizability to in vivo/humans not addressed in abstract"
    ],
    "evidence_strength": "low",
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    "peer_reviewed_likely": "yes",
    "keywords": [
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        "THz radiation",
        "neural stem cells",
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        "proliferation",
        "apoptosis",
        "DNA damage",
        "dose-dependent",
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            "weight": 0.1499999999999999944488848768742172978818416595458984375,
            "reason": "Terahertz/mmWave-adjacent high-frequency EMF topic; not explicitly 5G but relevant to emerging high-frequency technologies."
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}

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