Genotoxic and histopathological effects of 6 GHz radiofrequency electromagnetic radiation on rat liver tissue
Abstract
Category: Toxicology, Experimental Biology Tags: RF-EMR, liver, genotoxicity, histopathology, 6 GHz, electromagnetic fields, rats DOI: 10.1080/15368378.2025.2534381 URL: tandfonline.com Overview This study investigated the genotoxic and histopathological effects of 6 GHz (0.065 W/kg) Radiofrequency-Electromagnetic Radiation (RF-EMR) on rat liver tissue. A sham (control) group and a Radiofrequency Radiation (RFR) group, each with 10 adult male rats, were utilized for this experiment. The sham group received no treatment. The RFR group was subjected to 6 GHz RF-EMR for 4 hours per day over a period of 42 days. Findings - After exposure, liver tissues from both groups were examined. - Genotoxicity was assessed using the Comet Test, while Masson Trichrome and Hematoxylin Eosin staining methods were used for histopathological analysis. - The RFR group showed higher values in genetic damage index (GDI) and damaged cell percentage (DCP) compared to the sham group, though this increase was not statistically significant (p > 0.05). - Histopathologically, the RFR group exhibited more prominent portal inflammation, single cell necrosis, vascularity, and congestion relative to the control. Conclusion This study demonstrates that 6 GHz RF-EMR exposure can cause histopathological and DNA-level changes in rat liver tissue. Notably, there were no prior studies specifically evaluating the genotoxic and histopathological effects of 6 GHz RF-EMR, highlighting the significance of the biological impacts of this frequency band.
AI evidence extraction
Main findings
Compared with sham controls, the exposed group had higher genetic damage index and damaged cell percentage, but differences were not statistically significant (p>0.05). Histopathological findings in the exposed group were described as more prominent portal inflammation, single cell necrosis, vascularity, and congestion.
Outcomes measured
- Genotoxicity (Comet test; genetic damage index, damaged cell percentage)
- Histopathology of liver tissue (Masson Trichrome; Hematoxylin Eosin; portal inflammation, single cell necrosis, vascularity, congestion)
Limitations
- Genotoxicity increases were not statistically significant (p>0.05).
- Small group sizes (10 rats per group).
View raw extracted JSON
{
"study_type": "animal",
"exposure": {
"band": "RF",
"source": null,
"frequency_mhz": 6000,
"sar_wkg": 0.065000000000000002220446049250313080847263336181640625,
"duration": "4 hours/day for 42 days"
},
"population": "Adult male rats",
"sample_size": 20,
"outcomes": [
"Genotoxicity (Comet test; genetic damage index, damaged cell percentage)",
"Histopathology of liver tissue (Masson Trichrome; Hematoxylin Eosin; portal inflammation, single cell necrosis, vascularity, congestion)"
],
"main_findings": "Compared with sham controls, the exposed group had higher genetic damage index and damaged cell percentage, but differences were not statistically significant (p>0.05). Histopathological findings in the exposed group were described as more prominent portal inflammation, single cell necrosis, vascularity, and congestion.",
"effect_direction": "mixed",
"limitations": [
"Genotoxicity increases were not statistically significant (p>0.05).",
"Small group sizes (10 rats per group)."
],
"evidence_strength": "low",
"confidence": 0.7800000000000000266453525910037569701671600341796875,
"peer_reviewed_likely": "yes",
"keywords": [
"6 GHz",
"RF-EMR",
"radiofrequency electromagnetic radiation",
"rat",
"liver",
"genotoxicity",
"Comet assay",
"histopathology",
"SAR 0.065 W/kg"
],
"suggested_hubs": []
}
AI can be wrong. Always verify against the paper.
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