Reactive Oxygen Species: Potential Regulatory Molecules in Response to Hypomagnetic Field Exposure

Abstract

Reactive Oxygen Species: Potential Regulatory Molecules in Response to Hypomagnetic Field Exposure Bingfang Zhang, Lanxiang Tian. Reactive Oxygen Species: Potential Regulatory Molecules in Response to Hypomagnetic Field Exposure. Bioelectromagnetics. 2020 Sep 30. doi: 10.1002/bem.22299. Abstract Organisms, including humans, could be exposed to hypomagnetic fields (HMFs, intensity <5 μT), e.g. in some artificially shielded magnetic environments and during deep-space flights. Previous studies have demonstrated that HMF exposure could have negative effects on the central nervous system and embryonic development in many animals. However, the underlying mechanisms remain unknown. Studies have revealed that HMFs affect cellular reactive oxygen species (ROS) levels and thereby alter physiological and biological processes in organisms. ROS, the major component of highly active free radicals, which are ubiquitous in biological systems, were hypothesized to be the candidate signaling molecules that regulate diverse physiological processes in response to changes in magnetic fields. Here, we summarize the recent advances in the study of HMF-induced negative effects on the central nervous system and early embryonic development in animals, focusing on cellular ROS and their role in response to HMFs. Furthermore, we discuss the potential mechanism through which HMFs regulate ROS levels in cells. pubmed.ncbi.nlm.nih.gov

AI evidence extraction

Main findings

This review summarizes prior studies reporting that hypomagnetic field (HMF; <5 μT) exposure could have negative effects on the central nervous system and embryonic development in many animals. It highlights evidence that HMFs affect cellular ROS levels and discusses ROS as potential signaling/regulatory molecules mediating biological responses to HMF exposure.

Outcomes measured

• Reactive oxygen species (ROS) levels
• Central nervous system effects
• Early embryonic development effects

Limitations

• Underlying mechanisms are described as unknown in prior studies (mechanistic uncertainty).
• Narrative summary of existing studies; no new experimental data reported in the abstract.

Suggested hubs

• occupational-exposure (0.2)
  Mentions exposure in artificially shielded magnetic environments (could overlap with specialized/occupational settings).

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    "study_type": "review",
    "exposure": {
        "band": "ELF",
        "source": "hypomagnetic field (shielded environments; deep-space flights)",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Animals (general; includes mention of humans as potentially exposed)",
    "sample_size": null,
    "outcomes": [
        "Reactive oxygen species (ROS) levels",
        "Central nervous system effects",
        "Early embryonic development effects"
    ],
    "main_findings": "This review summarizes prior studies reporting that hypomagnetic field (HMF; <5 μT) exposure could have negative effects on the central nervous system and embryonic development in many animals. It highlights evidence that HMFs affect cellular ROS levels and discusses ROS as potential signaling/regulatory molecules mediating biological responses to HMF exposure.",
    "effect_direction": "harm",
    "limitations": [
        "Underlying mechanisms are described as unknown in prior studies (mechanistic uncertainty).",
        "Narrative summary of existing studies; no new experimental data reported in the abstract."
    ],
    "evidence_strength": "low",
    "confidence": 0.66000000000000003108624468950438313186168670654296875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "hypomagnetic field",
        "HMF",
        "<5 μT",
        "reactive oxygen species",
        "ROS",
        "central nervous system",
        "embryonic development",
        "mechanism"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.200000000000000011102230246251565404236316680908203125,
            "reason": "Mentions exposure in artificially shielded magnetic environments (could overlap with specialized/occupational settings)."
        }
    ]
}

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