Phenotypic and genotypic characterization of antioxidant enzyme system in human population exposed to mobile tower radiation

Abstract

Phenotypic and genotypic characterization of antioxidant enzyme system in human population exposed to mobile tower radiation Gulati S, Yadav A, Kumar N, Priya K, Aggarwal NK, Gupta R. Phenotypic and genotypic characterization of antioxidant enzyme system in human population exposed to radiation from mobile towers.Mol Cell Biochem. 2017 Aug 17. Abstract In the present era, cellular phones have changed the life style of human beings completely and have become an essential part of their lives. The number of cell phones and cell towers are increasing in spite of their disadvantages. These cell towers transmit radiation continuously without any interruption, so people living within 100s of meters from the tower receive 10,000 to 10,000,000 times stronger signal than required for mobile communication. In the present study, we have examined superoxide dismutase (SOD) enzyme activity, catalase (CAT) enzyme activity, lipid peroxidation assay, and effect of functional polymorphism of SOD and CAT antioxidant genes against mobile tower-induced oxidative stress in human population. From our results, we have found a significantly lower mean value of manganese superoxide dismutase (MnSOD) enzyme activity, catalase (CAT) enzyme activity, and a high value of lipid peroxidation assay in exposed as compared to control subjects. Polymorphisms in antioxidant MnSOD and CAT genes significantly contributed to its phenotype. In the current study, a significant association of genetic polymorphism of antioxidant genes with genetic damage has been observed in human population exposed to radiations emitted from mobile towers. ncbi.nlm.nih.gov

AI evidence extraction

Main findings

Compared with controls, exposed subjects had significantly lower mean MnSOD and catalase enzyme activity and higher lipid peroxidation. Polymorphisms in MnSOD and CAT genes significantly contributed to phenotype, and an association between antioxidant gene polymorphisms and genetic damage was reported in the exposed population.

Outcomes measured

• MnSOD enzyme activity
• Catalase (CAT) enzyme activity
• Lipid peroxidation assay
• Functional polymorphisms in MnSOD and CAT genes
• Genetic damage (association with antioxidant gene polymorphisms)

Limitations

• No sample size reported in abstract
• Exposure metrics (frequency, power density, SAR) not reported in abstract
• Study design details and control selection not described in abstract
• Potential confounding factors not described in abstract

Suggested hubs

• who-icnirp (0.2)
  Human health outcomes reported for RF exposure from mobile towers (base stations), relevant to guideline discussions.

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    "study_type": "case_control",
    "exposure": {
        "band": "RF",
        "source": "base station",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": null
    },
    "population": "Human population living within 100s of meters from mobile towers (exposed) compared to control subjects",
    "sample_size": null,
    "outcomes": [
        "MnSOD enzyme activity",
        "Catalase (CAT) enzyme activity",
        "Lipid peroxidation assay",
        "Functional polymorphisms in MnSOD and CAT genes",
        "Genetic damage (association with antioxidant gene polymorphisms)"
    ],
    "main_findings": "Compared with controls, exposed subjects had significantly lower mean MnSOD and catalase enzyme activity and higher lipid peroxidation. Polymorphisms in MnSOD and CAT genes significantly contributed to phenotype, and an association between antioxidant gene polymorphisms and genetic damage was reported in the exposed population.",
    "effect_direction": "harm",
    "limitations": [
        "No sample size reported in abstract",
        "Exposure metrics (frequency, power density, SAR) not reported in abstract",
        "Study design details and control selection not described in abstract",
        "Potential confounding factors not described in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7199999999999999733546474089962430298328399658203125,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "mobile tower radiation",
        "base station",
        "RF exposure",
        "oxidative stress",
        "MnSOD",
        "catalase",
        "lipid peroxidation",
        "polymorphism",
        "genetic damage"
    ],
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            "reason": "Human health outcomes reported for RF exposure from mobile towers (base stations), relevant to guideline discussions."
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}

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