Impact of EMR emitted by monitors on cellular membrane structure and protective antioxidant effect of vitamin A - In vitro study

Abstract

Impact of EMR emitted by monitors on cellular membrane structure and protective antioxidant effect of vitamin A - In vitro study Lewicka M, Henrykowska G, Zawadzka M, Rutkowski M, Pacholski K, Buczyński A. Impact of electromagnetic radiation emitted by monitors on changes in the cellular membrane structure and protective antioxidant effect of vitamin A - In vitro study. Int J Occup Med Environ Health. 2017 Jul 14;30(5):695-703. doi: 10.13075/ijomeh.1896.00851. Abstract OBJECTIVES: The increasing number of devices emitting electromagnetic radiation (EMR) in people's everyday life attracted the attention of researchers because of possible adverse effects of this factor on living organisms. One of the EMR effect may be peroxidation of lipid membranes formed as a result of free radical process. The article presents the results of in vitro studies aimed at identifying changes in malondialdehyde (MDA) concentration - a marker of lipid peroxidation and antioxidant role of vitamin A during the exposure of blood platelets to electromagnetic radiation generated by liquid-crystal-display (LCD) monitors. MATERIAL AND METHODS: Electromagnetic radiation emitted by LCD monitors is characterized by parameters: 1 kHz frequency and 220 V/m intensity (15 cm from display screen). The time of exposure was 30 and 60 min. The study was conducted on porcine blood platelets. The samples were divided into 6 groups: unexposed to radiation, unexposed + vitamin A, exposed for 30 min, exposed for 30 min + vitamin A, exposed for 60 min, exposed for 60 min + vitamin A. RESULTS: The MDA concentration in blood platelets increases significantly as compared to control values after 60 min of exposure to EMR. A significant decrease in MDA concentration after the addition of vitamin A was noticed. In the blood samples exposed to EMR for 30 and 60 min the MDA concentration was significantly increased by addition of vitamin A. CONCLUSIONS: The results show the possibly negative effect of electromagnetic radiation on the cellular membrane structure manifested by changes in malondialdehyde concentration and indicate a possible protective role of vitamin A in this process. ncbi.nlm.nih.gov Mortazavi SMJ. Letter to the Editor (July 26, 2017) concerning the paper "Impact of electromagnetic radiation emitted by monitors on changes in the cellular membrane structure and protective antioxidant effect of vitamin A - In vitro study". Int J Occup Med Environ Health. 2018 Jan 15;31(3):371-372. doi: 10.13075/ijomeh.1896.01245. ijomeh.eu by-monitors-on-changes-in,80565,0,2.html

AI evidence extraction

Main findings

EMR from LCD monitors (1 kHz, 220 V/m at 15 cm) was associated with a significant increase in MDA concentration after 60 min compared with controls. The abstract reports a significant decrease in MDA after adding vitamin A, but also states that in samples exposed for 30 and 60 min MDA was significantly increased by addition of vitamin A.

Outcomes measured

• Malondialdehyde (MDA) concentration (lipid peroxidation marker)
• Cellular membrane structure changes (via lipid peroxidation)
• Effect of vitamin A on MDA during EMR exposure

Limitations

• In vitro model using porcine blood platelets; generalizability to humans not established in abstract
• Sample size not reported in abstract
• Exposure characterization limited to frequency and electric field intensity at a single distance; other dosimetry not reported
• Findings regarding vitamin A appear internally inconsistent within the abstract

Suggested hubs

• occupational-exposure (0.55)
  Study published in an occupational/environmental health journal and examines EMR from monitors, a potential workplace exposure.

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    "exposure": {
        "band": "ELF",
        "source": "LCD monitor",
        "frequency_mhz": 0.001000000000000000020816681711721685132943093776702880859375,
        "sar_wkg": null,
        "duration": "30 and 60 min"
    },
    "population": "Porcine blood platelets (in vitro)",
    "sample_size": null,
    "outcomes": [
        "Malondialdehyde (MDA) concentration (lipid peroxidation marker)",
        "Cellular membrane structure changes (via lipid peroxidation)",
        "Effect of vitamin A on MDA during EMR exposure"
    ],
    "main_findings": "EMR from LCD monitors (1 kHz, 220 V/m at 15 cm) was associated with a significant increase in MDA concentration after 60 min compared with controls. The abstract reports a significant decrease in MDA after adding vitamin A, but also states that in samples exposed for 30 and 60 min MDA was significantly increased by addition of vitamin A.",
    "effect_direction": "mixed",
    "limitations": [
        "In vitro model using porcine blood platelets; generalizability to humans not established in abstract",
        "Sample size not reported in abstract",
        "Exposure characterization limited to frequency and electric field intensity at a single distance; other dosimetry not reported",
        "Findings regarding vitamin A appear internally inconsistent within the abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "electromagnetic radiation",
        "LCD monitor",
        "1 kHz",
        "electric field",
        "220 V/m",
        "blood platelets",
        "porcine",
        "malondialdehyde",
        "lipid peroxidation",
        "vitamin A",
        "antioxidant"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.5500000000000000444089209850062616169452667236328125,
            "reason": "Study published in an occupational/environmental health journal and examines EMR from monitors, a potential workplace exposure."
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