Spatial memory recovery in Alzheimer's rat model by ELF EMF exposure

Abstract

Spatial memory recovery in Alzheimer's rat model by ELF EMF exposure Akbarnejad Z, Esmaeilpour K, Shabani M, Asadi-Shekaari M, Saeedi Goraghani M, Ahmadi-Zeidabadi M. Spatial memory recovery in Alzheimer's rat model by electromagnetic field exposure. Int J Neurosci. 2017 Dec 20:1-6. doi: 10.1080/00207454.2017.1411353. Abstract INTRODUCTION: Although studies have shown a potential association between extremely low frequency electromagnetic fields (ELF-EMFs) exposure and Alzheimer's disease (AD), few studies have been conducted to investigate the effects of weak magnetic fields on brain functions such as cognitive functions in animal models. Therefore, this study aimed to investigate the effect of ELF-EMF exposure (50 Hz, 10 mT) on spatial learning and memory changes in AD rats. METHODS: Amyloid-β (Aβ) 1-42 was injected into lateral ventricle to establish an AD rat model. The rats were divided into six groups: Group I (control); Group II (surgical sham); Group III (AD) Alzheimer's rat model; Group IV (MF) rats exposed to ELF-MF for 14 consecutive days; Group V (Aβ injection+M) rats exposed to magnetic field for 14 consecutive days from day 0 to 14 days after the Aβ peptide injection; Group VI (AD+M) rats exposed to magnetic field for 14 consecutive days after 2 weeks of Aβ peptide injection from 14th to 28th day . Morris water maze investigations were performed. RESULTS: AD rats showed a significant impairment in learning and memory compared to control rats. The results showed that ELF-MF improved the learning and memory impairments in Aβ injection+M and AD+M groups. CONCLUSION: Our results showed that application of ELF-MF not only has improving effect on different cognitive disorder signs of AD animals, but also disrupts the processes of AD rat model formation. ncbi.nlm.nih.gov

AI evidence extraction

Main findings

Alzheimer’s disease (Aβ-injected) rats showed significant impairment in learning and memory versus controls. ELF magnetic field exposure (50 Hz, 10 mT) for 14 consecutive days improved learning and memory impairments in the Aβ injection+M and AD+M groups.

Outcomes measured

• Spatial learning and memory (Morris water maze)

Limitations

• Sample size not reported in abstract
• Details of randomization/blinding not reported in abstract
• Only behavioral outcomes (Morris water maze) described in abstract

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    "study_type": "animal",
    "exposure": {
        "band": "ELF",
        "source": "magnetic field exposure",
        "frequency_mhz": 5.00000000000000023960868011929647991564706899225711822509765625e-5,
        "sar_wkg": null,
        "duration": "14 consecutive days"
    },
    "population": "Rats (amyloid-β 1-42 intracerebroventricular injection Alzheimer’s disease model)",
    "sample_size": null,
    "outcomes": [
        "Spatial learning and memory (Morris water maze)"
    ],
    "main_findings": "Alzheimer’s disease (Aβ-injected) rats showed significant impairment in learning and memory versus controls. ELF magnetic field exposure (50 Hz, 10 mT) for 14 consecutive days improved learning and memory impairments in the Aβ injection+M and AD+M groups.",
    "effect_direction": "benefit",
    "limitations": [
        "Sample size not reported in abstract",
        "Details of randomization/blinding not reported in abstract",
        "Only behavioral outcomes (Morris water maze) described in abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "extremely low frequency",
        "ELF-EMF",
        "ELF-MF",
        "50 Hz",
        "10 mT",
        "Alzheimer's disease",
        "amyloid-beta 1-42",
        "rat model",
        "Morris water maze",
        "spatial memory",
        "learning",
        "cognition"
    ],
    "suggested_hubs": []
}

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