Physiopathological effects of quercetin on oxidative stress from 4.5 g mobile phone radiation exposed to liver tissue of rat

Abstract

Physiopathological effects of quercetin on oxidative stress from 4.5 g mobile phone radiation exposed to liver tissue of rat Postaci I, Coskun O, Senol N, Aslankoc R, Comlekci S. The physiopathological effects of quercetin on oxidative stress in radiation of 4.5 g mobile phone exposed liver tissue of rat. Bratisl Lek Listy. 2018;119(8):481-489. doi: 10.4149/BLL_2018_088. Abstract OBJECTIVE: The study was aimed to evaluate the physiopathological consideration of the effects of electromagnetic field (EMF) from the radiation of 4.5 G mobile phones on the liver tissue of rats and quercetin (Qu) applied as an antioxidant for reducing these effects. METHODS: Male Wistar-Albino rats were divided into four groups with 8 rats in each group. Group 1 (control group), Group 2 (sham group), Group 3 (EMF group) and Group 4 (EMF + Qu). From the animals sacrificed at the end of the 30th day; liver tissues were taken for histopathological and immunohistochemical examinations. RESULTS: In the liver tissue of the electromagnetic field group; dilatation of sinusitis was determined to be higher than in the sham group. It was concluded that the concentration of caspase-3 and TNF-α immunopositive cells was in the EMF group (+3) level and also the immunostaining was stronger, it caused an increase in malondialdehyde level, the difference between the groups was statistically significant, in terms of superoxide dismutase, catalase activities, the difference was not significant. CONCLUSION: It was determined that 2600 MHz EMF exposure caused damage to the liver, 100 mg/kg/day quercetin was not sufficient to prevent this damage (Tab. 5, Fig. 15, Ref. 27). bit.ly

AI evidence extraction

Main findings

Compared with sham, the EMF group showed higher sinusoid dilatation, stronger caspase-3 and TNF-α immunostaining (+3 level), and increased malondialdehyde; SOD and catalase activities did not differ significantly between groups. The authors concluded that 2600 MHz EMF exposure caused liver damage and that quercetin (100 mg/kg/day) was not sufficient to prevent this damage.

Outcomes measured

• Liver histopathology (sinusoid dilatation)
• Caspase-3 immunopositive cells
• TNF-α immunopositive cells
• Malondialdehyde (MDA) level
• Superoxide dismutase (SOD) activity
• Catalase activity

Limitations

• No SAR or exposure intensity details reported in the abstract
• Small group sizes (8 rats per group)
• Exposure description includes '4.5 G mobile phone radiation' but protocol details are not provided in the abstract

Suggested hubs

• 5g-policy (0.25)
  Mentions '4.5 G' and 2600 MHz mobile phone EMF exposure (cellular band context), though this is an animal study rather than policy.

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": "mobile phone",
        "frequency_mhz": 2600,
        "sar_wkg": null,
        "duration": "30 days"
    },
    "population": "Male Wistar-Albino rats",
    "sample_size": 32,
    "outcomes": [
        "Liver histopathology (sinusoid dilatation)",
        "Caspase-3 immunopositive cells",
        "TNF-α immunopositive cells",
        "Malondialdehyde (MDA) level",
        "Superoxide dismutase (SOD) activity",
        "Catalase activity"
    ],
    "main_findings": "Compared with sham, the EMF group showed higher sinusoid dilatation, stronger caspase-3 and TNF-α immunostaining (+3 level), and increased malondialdehyde; SOD and catalase activities did not differ significantly between groups. The authors concluded that 2600 MHz EMF exposure caused liver damage and that quercetin (100 mg/kg/day) was not sufficient to prevent this damage.",
    "effect_direction": "harm",
    "limitations": [
        "No SAR or exposure intensity details reported in the abstract",
        "Small group sizes (8 rats per group)",
        "Exposure description includes '4.5 G mobile phone radiation' but protocol details are not provided in the abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "rat",
        "liver",
        "mobile phone",
        "EMF",
        "2600 MHz",
        "oxidative stress",
        "quercetin",
        "caspase-3",
        "TNF-α",
        "malondialdehyde"
    ],
    "suggested_hubs": [
        {
            "slug": "5g-policy",
            "weight": 0.25,
            "reason": "Mentions '4.5 G' and 2600 MHz mobile phone EMF exposure (cellular band context), though this is an animal study rather than policy."
        }
    ]
}

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