Effects of Mobile Phone Exposure on Mast Cells in Rat Dura Mater

Abstract

Effects of Mobile Phone Exposure on Mast Cells in Rat Dura Mater Tumkaya L, Kalkan Y, Gokce FM, Erdivanli B, Yilmaz A, Bahceci I, Yazici ZA, Mercantepe T. The Effects of Mobile Phone Exposure on Mast Cells in Rat Dura Mater. Int J Morphology. 37(2):719-723. Jun 2019. Abstract Mobile phone use has increased rapidly. The central nervous system has been shown to be adversely affected by its electromagnetic field (EMF) resulting in headache and sleep disturbances. How the cells make up the CNS and are affected by EMF is unclear. However, because of their central role in inflammation through diverse stimuli including radiation, this study aimed to investigate the effects of electromagnetic fields induced by mobile phones on mast cells in rat dura mater. A total of 18 adult, female, Sprague-Dawley rats were divided into two groups. The choice of female rats for his study was based on recent surveys demonstrating that mobile phone use is more frequent and prolonged among females. The study group was exposed to 900 MHz electromagnetic field (1 h/day for 45 days). In the end of the study, duramater tissue was extracted and stained using Toluidine blue. Mast cells were counted and results were analysed using Student t test. Mean mast cell number was 202.33 +/- 982 and 456.78 +/- 35.01 in the control and study groups, respectively (p<0.05). Analysis of serum electrolyte and immunoglobulin E levels showed no statistically significant difference between the two groups (p>0.05). The study showed that mobile phone exposure increased mast cell number and degranulation in rat dura mater. Further studies arc required to evaluate the clinical implications of these findings. Open access paper: scielo.conicyt.cl

AI evidence extraction

Main findings

Rats exposed to a 900 MHz electromagnetic field for 1 h/day for 45 days had a higher mean mast cell number in dura mater than controls (p<0.05). Serum electrolyte and IgE levels did not differ significantly between groups (p>0.05). The authors report increased mast cell degranulation in the exposed group.

Outcomes measured

• Mast cell number in rat dura mater
• Mast cell degranulation in rat dura mater
• Serum electrolyte levels
• Serum immunoglobulin E (IgE) levels

Limitations

• No SAR or exposure intensity details reported in the abstract
• Small sample size (n=18)
• Animal model; clinical implications not established
• Only female rats studied

Suggested hubs

• mobile-phones-rf (0.9)
  Study examines 900 MHz mobile phone EMF exposure effects in rats.

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        "source": "mobile phone",
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        "sar_wkg": null,
        "duration": "1 h/day for 45 days"
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    "population": "Adult, female Sprague-Dawley rats",
    "sample_size": 18,
    "outcomes": [
        "Mast cell number in rat dura mater",
        "Mast cell degranulation in rat dura mater",
        "Serum electrolyte levels",
        "Serum immunoglobulin E (IgE) levels"
    ],
    "main_findings": "Rats exposed to a 900 MHz electromagnetic field for 1 h/day for 45 days had a higher mean mast cell number in dura mater than controls (p<0.05). Serum electrolyte and IgE levels did not differ significantly between groups (p>0.05). The authors report increased mast cell degranulation in the exposed group.",
    "effect_direction": "harm",
    "limitations": [
        "No SAR or exposure intensity details reported in the abstract",
        "Small sample size (n=18)",
        "Animal model; clinical implications not established",
        "Only female rats studied"
    ],
    "evidence_strength": "low",
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    "peer_reviewed_likely": "unknown",
    "keywords": [
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