The Effects of Prenatal Radiation of Mobile Phones on White Matter in Cerebellum of Rat Offspring

Abstract

The Effects of Prenatal Radiation of Mobile Phones on White Matter in Cerebellum of Rat Offspring Mei-Li Yang, Shan-Yan Hong, Hong-Hong Huang, Guo-Rong Lyu, Ling-Xing Wang. [The Effects of Prenatal Radiation of Mobile Phones on White Matter in Cerebellum of Rat Offspring] [Article in Chinese]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 Jan 28;36(1):77-81. DOI: 10.12047/j.cjap.5880.2020.017. Abstract Objective: To evaluate the effects of prenatal radiation of 850 -1,900 MHz mobile phone on white matter in cerebellum of adult rat offspring. Methods: Pregnant rats were randomly divided into short term maternal radiation group, long term maternal radiation group and control group. Rats in short term and long term maternal radiation group were exposed to 6 h/d and 24 h/d mobile phone radiation during 1-17 days of pregnancy, respectively. The cerebellums of offspring rats at the age of 3 month (n＝8) were taken. Cell morphology in cerebellum was studied by hematoxylin-eosin (HE) staining. The expressions of myelin basic protein (MBP), neurofilament-L (NF-L) and glial fibrillary acidic protein (GFAP) in cerebellum of rat offspring were detected by immunohistochemistry and Western blot. Results: Compared to control group, the morphological changes of purkinje cells in cerebellum were obvious in rat offspring of short term and long term maternal radiation group. Compared to control group, decreased MBP and NF-L expressions and increased GFAP expression were observed in long term maternal radiation group(all P ＜0.05). Compared to short term radiation group, the expressions of MBP and NF-L were down-regulated (all P ＜0.05) and the expression of GFAP was up- regulated(P＜0.05) in long term radiation group. Conclusion: Prenatal mobile phone radiation might lead to the damage of myelin and axon with activity of astrocytes in cerebellum of male rat offspring, which is related to the extent of radiation. pubmed.ncbi.nlm.nih.gov

AI evidence extraction

Main findings

Compared with controls, offspring in both exposure groups showed obvious morphological changes of Purkinje cells. In the long-term exposure group, MBP and NF-L were decreased and GFAP increased versus controls (P<0.05), and these changes were greater than in the short-term group.

Outcomes measured

• Cerebellum histology (Purkinje cell morphology; HE staining)
• Myelin basic protein (MBP) expression (immunohistochemistry, Western blot)
• Neurofilament-L (NF-L) expression (immunohistochemistry, Western blot)
• Glial fibrillary acidic protein (GFAP) expression (immunohistochemistry, Western blot)

Limitations

• No SAR or exposure intensity metrics reported in abstract
• Small sample size reported for offspring at 3 months (n=8)
• Sex-specific findings unclear (male offspring mentioned only in conclusion)
• Exposure description lacks details on distance/device configuration and dosimetry

Suggested hubs

• rf-mobile-phones (0.9)
  Prenatal exposure to mobile phone RF (850–1900 MHz) assessed in rats.

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    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": "mobile phone",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "Exposure during gestational days 1–17; 6 h/day (short-term) or 24 h/day (long-term)"
    },
    "population": "Pregnant rats and their 3-month-old offspring (male offspring mentioned in conclusion)",
    "sample_size": 8,
    "outcomes": [
        "Cerebellum histology (Purkinje cell morphology; HE staining)",
        "Myelin basic protein (MBP) expression (immunohistochemistry, Western blot)",
        "Neurofilament-L (NF-L) expression (immunohistochemistry, Western blot)",
        "Glial fibrillary acidic protein (GFAP) expression (immunohistochemistry, Western blot)"
    ],
    "main_findings": "Compared with controls, offspring in both exposure groups showed obvious morphological changes of Purkinje cells. In the long-term exposure group, MBP and NF-L were decreased and GFAP increased versus controls (P<0.05), and these changes were greater than in the short-term group.",
    "effect_direction": "harm",
    "limitations": [
        "No SAR or exposure intensity metrics reported in abstract",
        "Small sample size reported for offspring at 3 months (n=8)",
        "Sex-specific findings unclear (male offspring mentioned only in conclusion)",
        "Exposure description lacks details on distance/device configuration and dosimetry"
    ],
    "evidence_strength": "low",
    "confidence": 0.7399999999999999911182158029987476766109466552734375,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "prenatal exposure",
        "mobile phone radiation",
        "850–1900 MHz",
        "rat offspring",
        "cerebellum",
        "white matter",
        "myelin basic protein",
        "neurofilament-L",
        "GFAP",
        "Purkinje cells"
    ],
    "suggested_hubs": [
        {
            "slug": "rf-mobile-phones",
            "weight": 0.90000000000000002220446049250313080847263336181640625,
            "reason": "Prenatal exposure to mobile phone RF (850–1900 MHz) assessed in rats."
        }
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}

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