An Investigation Into the Effects of Long-Term 50-Hz Power-Frequency Electromagnetic Field Exposure on Hematogram, Blood Chemistry, Fibrosis, and Oxidant Stress Status in the Liver and the Kidney From Sprague- Dawley Rats

PAPER manual Bioelectromagnetics 2020 Animal study Effect: no_effect Evidence: Low

Read original paper → DOI: 10.1002/bem.22291 PMID: 32841426 Evidence Lab

Abstract

An Investigation Into the Effects of Long-Term 50-Hz Power-Frequency Electromagnetic Field Exposure on Hematogram, Blood Chemistry, Fibrosis, and Oxidant Stress Status in the Liver and the Kidney From Sprague- Dawley Rats Yemao Zhang, Jin Wang, Xingfa Liu, Lijian Ding, Xiong Wu, Mengying He, Huiying Hou, Guoran Ruan, Jinsheng Lai, Chen Chen. An Investigation Into the Effects of Long-Term 50-Hz Power-Frequency Electromagnetic Field Exposure on Hematogram, Blood Chemistry, Fibrosis, and Oxidant Stress Status in the Liver and the Kidney From Sprague-Dawley Rats. Bioelectromagnetics. 2020 Aug 25. doi: 10.1002/bem.22291. Abstract Power-frequency electromagnetic fields (PF-EMFs) at 50 Hz are potential health risk factors. This study aimed to explore the effects of long-term exposure to 50-Hz PF-EMFs on general physiological conditions in Sprague- Dawley (SD) rats. During a 24-week exposure period, the body mass and water and food intake of the animals were recorded regularly. The hematologic parameters were detected every 12 weeks, and blood chemistry analyses were performed every 4 weeks. After sacrifice, morphology was identified by hematoxylin-eosin, Masson, and immunohistochemical staining. Fibrosis-related gene expression and oxidative stress status were also detected. Compared with the control group, exposure to 30, 100, or 500 μT PF-EMF did not exert any effect on body mass, food intake, or water intake. Similarly, no significant differences were found in hematologic parameters or blood chemistry analyses among these groups. Furthermore, morphological assays showed that exposure to PF-EMFs had no influence on the structure of the liver or kidney. Finally, fibrosis-related gene expression and oxidative stress status were unaltered by PF-EMF exposure. The present study indicates that 24 weeks of exposure to PF-EMFs at intensities of 30, 100, or 500 μT might not affect hemograms, blood chemistry, fibrosis, or oxidative stress in the liver or kidney in SD rats. pubmed.ncbi.nlm.nih.gov

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

no_effect

Population

Sprague-Dawley rats

Sample size

—

Exposure

ELF power-frequency electromagnetic fields · 24 weeks

Evidence strength

Low

Confidence: 78% · Peer-reviewed: yes

Main findings

Compared with controls, 24 weeks of 50-Hz PF-EMF exposure at 30, 100, or 500 μT showed no significant effects on body mass, food and water intake, hematologic parameters, or blood chemistry. Histology indicated no influence on liver or kidney structure, and fibrosis-related gene expression and oxidative stress status were reported as unaltered.

Outcomes measured

Body mass
Food intake
Water intake
Hematologic parameters (hematogram)
Blood chemistry
Liver morphology/structure (histology)
Kidney morphology/structure (histology)
Fibrosis-related gene expression (liver/kidney)
Oxidative stress status (liver/kidney)

Limitations

Sample size not reported in provided abstract/metadata
Exposure metric reported in μT; other dosimetry details not provided in abstract (e.g., setup specifics)

Suggested hubs

occupational-exposure (0.35)
Study examines 50-Hz power-frequency EMF exposure, relevant to power/industrial ELF exposure contexts.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "ELF",
        "source": "power-frequency electromagnetic fields",
        "frequency_mhz": null,
        "sar_wkg": null,
        "duration": "24 weeks"
    },
    "population": "Sprague-Dawley rats",
    "sample_size": null,
    "outcomes": [
        "Body mass",
        "Food intake",
        "Water intake",
        "Hematologic parameters (hematogram)",
        "Blood chemistry",
        "Liver morphology/structure (histology)",
        "Kidney morphology/structure (histology)",
        "Fibrosis-related gene expression (liver/kidney)",
        "Oxidative stress status (liver/kidney)"
    ],
    "main_findings": "Compared with controls, 24 weeks of 50-Hz PF-EMF exposure at 30, 100, or 500 μT showed no significant effects on body mass, food and water intake, hematologic parameters, or blood chemistry. Histology indicated no influence on liver or kidney structure, and fibrosis-related gene expression and oxidative stress status were reported as unaltered.",
    "effect_direction": "no_effect",
    "limitations": [
        "Sample size not reported in provided abstract/metadata",
        "Exposure metric reported in μT; other dosimetry details not provided in abstract (e.g., setup specifics)"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "yes",
    "keywords": [
        "50 Hz",
        "power-frequency electromagnetic fields",
        "PF-EMF",
        "ELF",
        "Sprague-Dawley rats",
        "hematogram",
        "blood chemistry",
        "fibrosis",
        "oxidative stress",
        "liver",
        "kidney"
    ],
    "suggested_hubs": [
        {
            "slug": "occupational-exposure",
            "weight": 0.34999999999999997779553950749686919152736663818359375,
            "reason": "Study examines 50-Hz power-frequency EMF exposure, relevant to power/industrial ELF exposure contexts."
        }
    ]
}

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AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

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