Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone

PAPER manual Med Science 2024 Animal study Effect: mixed Evidence: Low

Read original paper → Evidence Lab

Abstract

Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone radiofrequency electromagnetic field Arslan B, Aras N, Yaman S, Comelekoglu U. Investigation of genetic stress parameters in brain tissues of rats exposed to 1.8 GHz cell phone radiofrequency electromagnetic field. Med Science. 2024;13(1):78- 82. Abstract Heat Shock Proteins (HSPs) may induce various cellular processes, including replication, apoptosis, cell- cycle progression. Mitogen-activated protein kinase (MAPK) cascades are the primary mechanism that mediates the cellular stress response to extracellular stimuli and regulates transcriptional activity. It has been shown that mobile phone exposure can stimulate the Hsp27/p38MAPK stress pathway. In this study, twenty-seven mature female Wistar albino rats were exposed to 1.8 GHz radiofrequency electromagnetic field (RF-EMF) 2h/day for 8 weeks (SAR: 0.06 W/kg). Hsp27 and p38MAPK gene expressions were investigated in rat brains. Rats were divided into groups sham-exposed, cage control, and 1.8 GHz RF-EMF exposed. Hsp27 and p38MAPK gene expression levels were investigated from the brain. p38MAPK expression was found to be upregulated in RF-EMF exposed group (p=0.018) Hsp27 expressions were not altered (p=0.897). In conclusion, long-term exposure to 1.8 GHz cell phone radiation can activate the Hsp27/p38MAPK stress pathway. It may cause several cellular disorders and can affect brain function. Open access paper: medicinescience.org

AI evidence extraction

At a glance

Study type

Animal study

Effect direction

mixed

Population

Mature female Wistar albino rats

Sample size

Exposure

RF mobile phone · 1800 MHz · 0.06 W/kg · 2 h/day for 8 weeks

Evidence strength

Low

Confidence: 78% · Peer-reviewed: unknown

Main findings

In rat brain tissue, p38MAPK gene expression was upregulated in the 1.8 GHz RF-EMF exposed group compared with controls (p=0.018). Hsp27 gene expression was not altered (p=0.897).

Outcomes measured

Hsp27 gene expression (brain)
p38MAPK gene expression (brain)

Limitations

Only female rats were studied
Outcome measures limited to Hsp27 and p38MAPK gene expression in brain tissue
Exposure details beyond frequency, SAR, and schedule are not described in the abstract

Suggested hubs

mobile-phones (0.9)
Study examines 1.8 GHz cell phone RF-EMF exposure.
animal-studies (0.85)
Experimental exposure study in rats.

View raw extracted JSON

{
    "study_type": "animal",
    "exposure": {
        "band": "RF",
        "source": "mobile phone",
        "frequency_mhz": 1800,
        "sar_wkg": 0.059999999999999997779553950749686919152736663818359375,
        "duration": "2 h/day for 8 weeks"
    },
    "population": "Mature female Wistar albino rats",
    "sample_size": 27,
    "outcomes": [
        "Hsp27 gene expression (brain)",
        "p38MAPK gene expression (brain)"
    ],
    "main_findings": "In rat brain tissue, p38MAPK gene expression was upregulated in the 1.8 GHz RF-EMF exposed group compared with controls (p=0.018). Hsp27 gene expression was not altered (p=0.897).",
    "effect_direction": "mixed",
    "limitations": [
        "Only female rats were studied",
        "Outcome measures limited to Hsp27 and p38MAPK gene expression in brain tissue",
        "Exposure details beyond frequency, SAR, and schedule are not described in the abstract"
    ],
    "evidence_strength": "low",
    "confidence": 0.7800000000000000266453525910037569701671600341796875,
    "peer_reviewed_likely": "unknown",
    "keywords": [
        "1.8 GHz",
        "RF-EMF",
        "cell phone",
        "rat",
        "brain",
        "Hsp27",
        "p38MAPK",
        "stress pathway",
        "gene expression",
        "SAR 0.06 W/kg"
    ],
    "suggested_hubs": [
        {
            "slug": "mobile-phones",
            "weight": 0.90000000000000002220446049250313080847263336181640625,
            "reason": "Study examines 1.8 GHz cell phone RF-EMF exposure."
        },
        {
            "slug": "animal-studies",
            "weight": 0.84999999999999997779553950749686919152736663818359375,
            "reason": "Experimental exposure study in rats."
        }
    ]
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract/metadata and may be incomplete or incorrect. This content is for informational purposes only and is not medical advice.

Comments

No comments yet.