This RF Safe commentary argues that if HHS and FDA pursue a “reset” on cellphone radiation policy, they should fund mechanistic, predictive biology rather than relying on literature summaries or general safety reassurances. It cites the NTP rat bioassays and a WHO-commissioned animal cancer systematic review (Mevissen et al., 2025) as motivation, emphasizing reported tissue-selective findings and non-monotonic dose patterns. The post proposes a mechanistic framework (“S4–Mito–Spin”) and calls for research to map boundary conditions across tissues and exposure parameters to inform standards beyond SAR/thermal assumptions.

An RF Safe commentary argues that a proposed “S4–mitochondria axis” provides a coherent mechanism for non-thermal RF/ELF biological effects, linking voltage-gated ion channel (VGIC) disruption to altered calcium signaling, mitochondrial ROS, and downstream cancer, reproductive, and immune impacts. The post cites several recent reviews and systematic reviews (including a WHO-commissioned animal carcinogenicity review and an SR4A corrigendum) as strengthening evidence for specific tumor and reproductive outcomes in animals. It concludes that regulatory positions emphasizing thermal limits and lack of mechanism are no longer defensible, presenting this as convergent evidence rather than scattered findings.

RF Safe’s “Executive Summary” argues that non-thermal radiofrequency/microwave exposures from modern wireless technologies can disrupt biological processes, proposing ion-channel voltage-sensor interference as a key mechanism leading to oxidative stress and inflammation. It cites animal studies (NTP and Ramazzini) and claims a WHO-commissioned 2025 systematic review found “high certainty” evidence of increased cancer in animals, and it points to epidemiological trends as suggestive. The piece also criticizes U.S. regulation as focused on thermal effects, highlighting FCC limits dating to 1996 and referencing a 2021 U.S. court ruling that faulted the FCC for not addressing non-thermal evidence.