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Non-thermal biological effects of radiofrequency electromagnetic radiation: Mechanistic insights into male reproductive vulnerability in the era of ubiquitous exposure
This narrative review discusses proposed non-thermal mechanisms by which chronic, low-intensity RF-EMR from ubiquitous wireless sources may affect male reproductive health. It highlights oxidative stress, mitochondrial dysfunction, impaired testosterone synthesis/steroidogenesis, and declines in sperm quality as reported outcomes. The authors argue that current SAR/thermal-based guidelines may not capture these endpoints and call for updated standards and precautionary measures.
Male Reproductive and Cellular Damage After Prenatal 3.5 GHz Radiation Exposure: One-Year Postnatal Effects
This animal study examined whether prenatal exposure to 3.5 GHz radiofrequency radiation (2 hours/day) affects male reproductive outcomes later in life. Male rat offspring assessed at 12 months showed multiple adverse testicular and cellular findings in exposed groups versus sham controls, including impaired spermatogenesis markers, increased abnormal sperm morphology, increased DNA damage, and increased apoptosis, with full-gestation exposure generally most pronounced. The authors interpret the results as evidence of persistent reproductive toxicity from prenatal exposure and call for further mechanistic work and precautionary actions.
Electromagnetic Field Stimulation Effects on Intrinsically Disordered Proteins and Their Role in Aging and Neurodegeneration
This review discusses preclinical studies suggesting non-ionizing EMF exposures can produce beneficial biological effects, while noting ongoing controversy about mechanisms. It reports evidence of EMF-associated conformational changes in intrinsically disordered proteins relevant to neurodegeneration and describes RF exposure conditions that activate proteostasis and autophagy in cell and animal models. The authors propose a quantum-biophysical framework involving the water-protein interface and suggest potential human applications within regulatory safety thresholds.