This numerical dosimetry study modeled localized RF exposure (3–30 GHz) in multi-layer human skin constructs including skin, fat, and muscle, with an added synthetic blood vessel model. Vascular modeling had negligible impact on peak spatial-averaged absorbed power density and a modest impact on peak temperature rise (about 8% at 3 GHz, <3% above 6 GHz). The authors conclude that including vasculature can refine predictions of localized thermal distributions for dosimetry accuracy.