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Showing results for: NF-κB

Mechanism first explanation of how the plasma membrane potential controls immune responses

Independent Voices RF Safe Nov 4, 2025

An RF Safe article argues that plasma membrane potential (Vm) is a key control variable for immune cell behavior by shaping ion driving forces, especially Ca2+ influx through CRAC channels and K+ channel–mediated hyperpolarization. It describes proposed links between Vm-regulated ion flux and downstream immune…

Restoring Bioelectric Timing Fidelity to Prevent Immune Dysregulation

Independent Voices RF Safe Nov 4, 2025

RF Safe argues that non-thermal biological effects from low-frequency/pulsed RF-EMF exposures can be explained by a “timing-fidelity” mechanism involving voltage-gated ion channel (VGIC) gating perturbations. The post links altered ion-channel timing to downstream immune signaling changes (e.g., Ca²⁺ dynamics,…

Alleviation of Inflammatory Conditions Caused by Extremely Low-Frequency Electromagnetic Field Exposure by .

Research RF Safe Research Library Jan 1, 2025

This in vitro study exposed RAW 264.7 cells to extremely low-frequency electromagnetic fields (ELF-EMF) and evaluated inflammatory signaling and related endpoints. The authors report that ELF-EMF increased nitric oxide and pro-inflammatory cytokines and was associated with increased NF-κB translocation and NFAT2…

Assessing the effect of selenium on cyclin D1 level and nuclear factor kappa b activity in NIH/3T3 fibroblast cells at 2100 MHz electromagnetic field exposure.

Research RF Safe Research Library Jan 1, 2023

This in vitro study examined NIH/3T3 fibroblast cells exposed to 2100 MHz EMF and evaluated cell viability, cyclin D1, and NF-κB activity, with and without 200 nM selenium. The abstract reports reduced cell viability and increased cyclin D1 and NF-κB activity after EMF exposure. Selenium supplementation was reported…

Short ELF-EMF Exposure Targets SIRT1/Nrf2/HO-1 Signaling in THP-1 Cells.

Research RF Safe Research Library Jan 1, 2020

This in vitro study examined 50 Hz, 1 mT ELF-EMF exposure in LPS-treated THP-1 cells for 1–24 hours. The authors report increased HO-1 expression and Nrf2-related signaling, with nuclear enrichment of HO-1 and modulation of SIRT1/NF-κB pathways. They interpret these molecular changes as suggesting a protective,…

Activation of TLR signalling regulates microwave radiation-mediated impairment of spermatogenesis in rat testis.

Research RF Safe Research Library Jan 1, 2018

This rat study examined whether microwave radiation affects Toll-like receptor (TLR) signaling in testis. The authors report increased TLR2-5 expression and elevated pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) after microwave exposure. Key phosphorylated components of TLR signaling (including NF-κB p65) were also…

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