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Melatonin ameliorates RF-EMR-induced reproductive damage by inhibiting ferroptosis through Nrf2 pathway activation

This animal study reports that prolonged RF-EMR exposure (2.45 GHz for 8 weeks) increased oxidative stress and ferroptosis in mouse testicular tissue and was associated with reduced sperm quality. Melatonin administration reportedly mitigated oxidative injury and inhibited ferroptosis. The abstract attributes the…

Electromagnetic field (50 Hz) enhance metabolic potential and induce adaptive/reprogramming response mediated by the increase of N6-methyladenosine RNA methylation in adipose-derived mesenchymal stem cells in vitro.

This in vitro study exposed adipose-derived mesenchymal stem cells to a 50 Hz electromagnetic field (1.5 mT) for 24 and 48 hours and assessed cellular responses. After 24 hours, the authors report increased N6-methyladenosine RNA methylation, increased expression of multiple stem cell markers, and changes in p21 and…

Melatonin protects rat cerebellar granule cells against electromagnetic field-induced increases in Na(+) currents through intracellular Ca(2+) release

This in vitro study examined extremely low-frequency electromagnetic field (ELF-EMF) effects on voltage-gated sodium (Nav) currents in rat cerebellar granule cells and whether melatonin modifies these effects. The abstract reports that 60 minutes of ELF-EMF exposure increased Nav current density, and that melatonin…

Down-regulation of metallothionein 1 and 2 after exposure to electromagnetic field in mouse testis.

This animal study examined mouse testis after 8 weeks of exposure to a 3 MT electromagnetic field (4 hours/day). The authors report significant histological changes (increased primary spermatocytes, increased Leydig cells, and increased basement membrane thickness) in exposed mice versus controls. MT1 and MT2…