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Exposure to 900 MHz electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats

Research RF Safe Research Library Mar 19, 2015

This animal study exposed 108 male Sprague-Dawley rats to 900 MHz EMF (1 mW/cm2) or sham for 14 or 28 days (3 h/day). The authors report that 28-day exposure was associated with impaired spatial memory, BBB permeability damage, and ultrastructural changes in hippocampus and cortex. They also report increased mkp-1…

2.45 GHz Microwave Radiation Impairs Learning and Spatial Memory via Oxidative/Nitrosative Stress Induced p53-Dependent/Independent Hippocampal Apoptosis: Molecular Basis and Underlying Mechanism

Research RF Safe Research Library Jan 1, 2015

This animal study exposed male Swiss mice to 2.45 GHz continuous-wave microwave radiation for 2 hours/day over 15, 30, or 60 days. The authors report increased hippocampal oxidative/nitrosative stress and increased apoptosis in neuronal and nonneuronal hippocampal subfields. They also report duration-dependent…

Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats

Research RF Safe Research Library Jan 1, 2015

This animal study evaluated repeated 1800 MHz EMF exposure (5 × 15 minutes) on lipid peroxidation (MDA) in Wistar rats, including healthy animals and those with CFA-induced inflammation, with and without tramadol. The authors report slightly elevated MDA in blood, brain, and kidneys in EMF-exposed conditions,…

The effects of radio-frequency electromagnetic fields on T cell function during development

Research RF Safe Research Library Jan 1, 2015

This animal study exposed developing Sprague Dawley rats to 2.14 GHz W-CDMA RF-EMF at a whole-body SAR of 0.2 W/kg for 9 weeks (20 h/day). No differences were reported in multiple T cell population measures across blood, spleen, and thymus. Some Th1/Th2-related genes were upregulated (notably in thymus), but serum…

[Effect of Low-Intensity 900 MHz Frequency Electromagnetic Radiation on Rat Brain Enzyme Activities Linked to Energy Metabolism].

Research RF Safe Research Library Jan 1, 2015

This animal study examined low-intensity 900 MHz electromagnetic radiation (25 μW/cm2) and its effects on rat brain and blood serum enzymes linked to energy metabolism. The authors report that brain creatine kinase activity was the most radiosensitive among the enzymes measured and propose it as a marker of RF…

[Early and Delayed Effects of Radio Frequency Electromagnetic Fields on the Reproductive Function and Functional Status of the Offspring of Experimental Animals].

Research RF Safe Research Library Jan 1, 2015

This experimental animal study examined RF EMF effects on reproduction in CBA mice and on the morphofunctional status of their offspring under two exposure models. The authors report that repeated short-term RF EMF exposure (5 days, 10 minutes per day, 1.2 mW/cm2) affected pregnancy course, litter number, fertility,…

The effect of exposure of rats during prenatal period to radiation spreading from mobile phones on renal development.

Research RF Safe Research Library Jan 1, 2015

This animal study exposed pregnant Sprague-Dawley rats to a 900 MHz electromagnetic field during the first 20 days of pregnancy and assessed prenatal renal development. The exposed group showed reported histopathological kidney changes and increased caspase-3 staining suggestive of higher apoptosis compared with…

The use of low-level electromagnetic fields to suppress atrial fibrillation.

Research RF Safe Research Library Jan 1, 2015

This animal study tested whether extremely low-level pulsed EMF (0.034 μG, 0.952 Hz) could suppress induced atrial fibrillation in 17 anesthetized dogs. EMF applied to cervical vagal trunks or across the chest was reported to suppress neural firing in the anterior right ganglionated plexi. The authors report that EMF…

2.45-GHz microwave irradiation adversely affects reproductive function in male mouse, Mus musculus by inducing oxidative and nitrosative stress

Research RF Safe Research Library Jan 1, 2014

This animal study exposed 12-week-old male Swiss strain mice to non-thermal low-level 2.45-GHz microwave radiation for 2 hours per day over 30 days (SAR 0.018 W/kg). The abstract reports reduced sperm count and viability, testicular structural changes, lower 3β-HSD activity and plasma testosterone, and increased…

Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats

Research RF Safe Research Library Jan 1, 2014

This animal study examined 2.45 GHz Wi-Fi exposure in a PTZ-induced epilepsy rat model using freshly isolated hippocampal and DRG neurons. The authors report that epilepsy increased Ca(2+) influx, oxidative stress markers, and apoptosis-related outcomes, and that Wi-Fi exposure produced additional increases in…

Pulsed electromagnetic field treatment enhances healing callus biomechanical properties in an animal model of osteoporotic fracture

Research RF Safe Research Library Jan 1, 2014

This animal study evaluated whether daily pulsed electromagnetic field (PEMF) treatments improve delayed fracture healing in skeletally mature ovariectomized (OVX) rats. By 6 weeks, PEMF-treated rats showed improved hard callus elastic modulus and radiographic evidence of better callus bridging compared with sham…

Effect of 950 MHz UHF electromagnetic radiation on biomarkers of oxidative damage, metabolism of UFA and antioxidants in the livers of young rats of different ages

Research RF Safe Research Library Jan 1, 2014

This animal study exposed rats of different early-life ages to 950 MHz UHF electromagnetic radiation for 30 minutes per day (SAR 1.0–1.3 W/kg) across gestation and/or early postnatal periods. The authors report no evidence of oxidative stress by TBARS or protein carbonyls, but report changes in fatty acid…

[The activity of prooxidant-antioxidant system in loach embryos under the action of microwave radiation].

Research RF Safe Research Library Jan 1, 2014

This animal study examined oxidative stress and antioxidant defenses in loach embryos exposed to GSM 900 MHz microwave radiation (SAR 1.1 W/kg) for 1–20 minutes during early embryogenesis. The authors report significant changes in lipid peroxidation products and altered antioxidant enzyme activities. They conclude…

[Effect of low-intensity 900 MHz frequency electromagnetic radiation on rat liver and blood serum enzyme activities].

Research RF Safe Research Library Jan 1, 2014

This animal study compared rat liver and blood serum enzyme activities after a total two-hour exposure to low-intensity 900 MHz electromagnetic fields delivered as either a single or fractional schedule. The authors report that creatine kinase (liver and serum) and serum alkaline phosphatase were the most sensitive…

[State of the reproductive systemin in male rats of 1st generation obtained from irradiated parents and exposed to electromagnetic radiation (897 MHz) during embryogenesis and postnatal development].

Research RF Safe Research Library Jan 1, 2014

This animal study examined prolonged 897 MHz electromagnetic radiation exposure (8 h/day) in first-generation male rats from irradiated parents, with exposure during embryogenesis and postnatal development. The abstract reports fewer births and a sex ratio shift toward more males. It also reports accelerated male…

[Modulating effect of weak combined magnetic fields on duration of mealworm beetle Tenebrio molitor metamorphosis stage].

Research RF Safe Research Library Jan 1, 2014

This animal study reports that combined static (42 μT) and very weak alternating (250 nT) magnetic fields can modulate the duration of metamorphosis in Tenebrio molitor pupae depending on the alternating-field frequency. A shorter pupal stage was reported at 4.4 Hz, an inhibiting effect at 32.2 Hz, and no noticeable…

Non-linear adaptive phenomena which decrease the risk of infection after pre-exposure to radiofrequency radiation.

Research RF Safe Research Library Jan 1, 2014

This animal study examined whether pre-exposure to radiofrequency radiation (from a GSM mobile phone) alters survival after subsequent Escherichia coli infection. The abstract reports higher survival in the group receiving both RF pre-exposure and bacterial challenge than in the group receiving only the bacterial…

The effect of extremely low frequency pulsed electromagnetic field on in vitro fertilization success rate in N MRI mice.

Research RF Safe Research Library Jan 1, 2014

This randomized comparative animal study tested whether extremely low frequency pulsed electromagnetic field exposure affects IVF success in NMRI mice. Mice in the experimental group were exposed to a 1.3 mT pulsed field at 4 kHz for 5 hours during the IVF process. Although the exposed group showed a higher IVF…

Effects of 900 MHz electromagnetic field emitted by cellular phones on electrocardiograms of guinea pigs.

Research RF Safe Research Library Jan 1, 2014

This animal study examined whether RF-EMF from cellular phones affects electrocardiograms in guinea pigs. Thirty guinea pigs were randomized to control (no exposure) or RF-EMF exposure (890–915 MHz; SAR 0.95 W/kg) for 12 hours per day over 30 days. The study reports no significant effects on ECG findings under these…

Spatial learning, monoamines and oxidative stress in rats exposed to 900 MHz electromagnetic field in combination with iron overload.

Research RF Safe Research Library Jan 1, 2014

This animal study tested whether 900 MHz EMF exposure, alone or combined with brain iron overload, affects cognition and brain biochemistry in Long-Evans rats. EMF-exposed rats showed impairment in an object exploration task and changes in monoamine content (notably in the hippocampus), while other spatial…

Reactive oxygen species elevation and recovery in Drosophila bodies and ovaries following short-term and long-term exposure to DECT base EMF.

Research RF Safe Research Library Jan 1, 2014

This animal study measured ROS in Drosophila bodies and ovaries after short- and long-term exposure to DECT base RF (1.88–1.90 GHz; SAR 0.009 W/kg). The abstract reports increased ROS in bodies after 6 h exposure and in ovaries after 0.5–1 h exposure, with apparent saturation under longer continuous exposure. It also…

Assessing of plasma protein denaturation induced by exposure to cadmium, electromagnetic fields and their combined actions on rat.

Research RF Safe Research Library Jan 1, 2014

This animal study examined whether cadmium, EMF exposure, or their combination affects oxidative damage and protein structure in rat plasma. The authors report increased oxidative protein damage markers and changes in protein-related measures after cadmium and/or EMF exposure. Effects were described as more…

Optimization of a therapeutic electromagnetic field (EMF) to retard breast cancer tumor growth and vascularity.

Research RF Safe Research Library Jan 1, 2014

This animal study evaluated a therapeutic 120 Hz pulsed EMF device (10–20 mT) in C3H mice bearing implanted murine mammary adenocarcinoma tumors. Across seven treated groups, EMF exposure over 12 days was reported to suppress tumor growth, with specific dose/time regimens described as most effective. The authors also…

[The effect of weak low-frequency magnetic fields on the intracellular calcium-dependent proteinases of fish].

Research RF Safe Research Library Jan 1, 2013

This animal study examined in vivo and in vitro effects of weak, low-frequency magnetic fields described as having resonance parameters for calcium ions. The authors report a considerable decrease in activity of calcium-dependent proteinases (calpains) in fish skeletal muscle and brain following exposure. The…

P-selectin expression in a colon tumor model exposed by sinusoidal electromagnetic fields.

Research RF Safe Research Library Jan 1, 2013

This animal study evaluated whether sinusoidal magnetic field exposure alters P-selectin expression in a rat colon tumor model. Rats exposed to 50 Hz, 5 mT for 6 h/day for 8 months showed no statistically significant change in P-selectin expression by immunohistochemistry. The authors indicate that further in vitro…

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