A Route to Chaotic Behavior of Single Neuron Exposed to External Electromagnetic Radiation.
Research
RF Safe Research Library
Jan 1, 2017
This computational study investigates nonlinear membrane-potential dynamics in a Fitzhugh-Nagumo single-neuron model that includes an external electromagnetic radiation term. The authors report that increasing the frequency of an external transmembrane current leads to mode selection among periodic, quasi-periodic,…
2.45 GHz Microwave Radiation Impairs Learning and Spatial Memory via Oxidative/Nitrosative Stress Induced p53-Dependent/Independent Hippocampal Apoptosis: Molecular Basis and Underlying Mechanism
Research
RF Safe Research Library
Jan 1, 2015
This animal study exposed male Swiss mice to 2.45 GHz continuous-wave microwave radiation for 2 hours/day over 15, 30, or 60 days. The authors report increased hippocampal oxidative/nitrosative stress and increased apoptosis in neuronal and nonneuronal hippocampal subfields. They also report duration-dependent…
Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats
Research
RF Safe Research Library
Jan 1, 2014
This animal study examined 2.45 GHz Wi-Fi exposure in a PTZ-induced epilepsy rat model using freshly isolated hippocampal and DRG neurons. The authors report that epilepsy increased Ca(2+) influx, oxidative stress markers, and apoptosis-related outcomes, and that Wi-Fi exposure produced additional increases in…
Assessment of the neurotoxic potential of exposure to 50Hz extremely low frequency electromagnetic fields (ELF-EMF) in naïve and chemically stressed PC12 cells
Research
RF Safe Research Library
Jan 1, 2014
This in vitro study tested acute (30 min) and sub-chronic (48 h) 50 Hz ELF-EMF exposure up to 1000 µT in naïve and chemically stressed PC12 cells. Across assays of Ca2+ homeostasis, ROS production, and membrane integrity, the study reports no consistent or measurable neurotoxic effects under the tested conditions.…
Neurodegenerative disease and magnetic field exposure in UK electricity supply workers
Research
RF Safe Research Library
Jan 1, 2014
This cohort study examined mortality from Alzheimer’s disease, motor neurone disease, and Parkinson’s disease among 73,051 UK electricity supply workers from 1973 to 2010. Occupational magnetic-field exposure was assessed using detailed calculations and analyzed using Poisson regression across lifetime, distant…
An ephaptic transmission model of CA3 pyramidal cells: an investigation into electric field effects.
Research
RF Safe Research Library
Jan 1, 2014
This paper presents a two-compartment computational model of CA3 pyramidal neurons to investigate how extracellular electric fields influence neuronal behavior via ephaptic transmission. The model is matched to subthreshold experimental responses at rest and used to analyze how DC and sinusoidal fields affect…
Exposure to extremely low-frequency electromagnetic fields inhibits T-type calcium channels via AA/LTE4 signaling pathway.
Research
RF Safe Research Library
Jan 1, 2014
This in vitro study examined 50 Hz ELF-EMF effects on human T-type calcium channels expressed in HEK293 cells and on native T-type channels in primary cultured mouse cortical neurons. The authors report that ELF-EMF (0.2 mT) inhibited Cav3.1, Cav3.2, and Cav3.3 channel activity without changing Cav3.2 expression or…
[Electromagnetic radiation of non-thermal intensity and short exposition as a sub-threshold irritant for the central nervous system].
Research
RF Safe Research Library
Jan 1, 2013
This article presents a generalization and analysis of the author's long-term materials on brain responses to low-intensity electromagnetic radiation (~500 microW/cm2, continuous or pulsed) after short exposure (~30 minutes). It describes experimental results at the level of single neurons, brain formations, and the…
Synchronization of neuron population subject to steady DC electric field induced by magnetic stimulation.
Research
RF Safe Research Library
Jan 1, 2013
This paper investigates, in an interneuronal network model, how a steady DC electric field induced by magnetic stimulation affects network coherence and synchronization. The authors report that coherence can exhibit a peak or plateau across a defined range of induced field values. Effects varied by network topology…
Role of cortical cell type and morphology in subthreshold and suprathreshold uniform electric field stimulation in vitro.
Research
RF Safe Research Library
Jan 1, 2009
This in vitro study examined how cortical neuron morphology and cell type relate to responses under subthreshold and suprathreshold uniform electric fields in rat motor cortex slices. The authors report that morphology correlates with subthreshold somatic polarization and that layer V pyramidal neurons are predicted…
[Effect of 1.8 GHz radiofrequency electromagnetic fields on gene expression of rat neurons].
Research
RF Safe Research Library
Jan 1, 2008
This in vitro study exposed primary cultured rat neurons to 1.8 GHz RF-EMF at an average SAR of 2 W/kg and assessed gene expression changes. The authors report multiple differentially expressed genes after 24 h intermittent exposure and confirm exposure-dependent changes in Egr-1, Mbp, and Plp by semi-quantitative…