Evaluation of Cytotoxic and Genotoxic Effects of Extremely Low-frequency Electromagnetic Field on Mesenchymal Stromal Cells.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study evaluated whether a therapeutic extremely low-frequency EMF exposure (5 Hz, 0.4 mT) causes cytotoxic or genotoxic effects in a human mesenchymal stromal cell line. Cells were exposed for 20 minutes per day, three times per week, for two weeks and assessed for viability, proliferation, and…
Effects of Fifty-Hertz Electromagnetic Fields on Granulocytic Differentiation of ATRA-Treated Acute Promyelocytic Leukemia NB4 Cells.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study examined whether 50 Hz, 2 mT extremely low-frequency electromagnetic fields affect ATRA-driven granulocytic differentiation in NB4 acute promyelocytic leukemia cells. The authors report reduced proliferation and enhanced maturation/differentiation markers with ELF-EMF exposure. They also report…
Case-Control Study on Occupational Exposure to Extremely Low-Frequency Electromagnetic Fields and the Association with Meningioma.
Research
RF Safe Research Library
Jan 1, 2018
This case-control analysis assessed occupational extremely low-frequency electromagnetic field (ELF-EMF) exposure and meningioma using the INTEROCC ELF-EMF job-exposure matrix. Cumulative, average, and maximum job exposure metrics were evaluated. The study reports no increased meningioma risk in any exposure…
Extremely low-frequency electromagnetic fields accelerates wound healing modulating MMP-9 and inflammatory cytokines.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study used a scratch wound model in human immortalized keratinocytes (HaCaT) to examine effects of extremely low-frequency electromagnetic fields (ELF-EMF). ELF-EMF exposure was reported to accelerate wound closure compared with sham and to increase inflammatory cytokine expression/release. The authors…
Extremely low-frequency electromagnetic field (EMF) generates alterations in the synthesis and secretion of oestradiol-17β (E) in uterine tissues: An in vitro study.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study exposed porcine endometrial and myometrial slices to extremely low-frequency EMF (50 or 120 Hz, 8 mT) for 2 or 4 hours, with or without progesterone. The authors report frequency- and time-dependent changes in oestradiol-17β secretion and CYP19A3 mRNA expression, with fewer changes when…
Effect of extremely low-frequency electromagnetic fields on antioxidant activity in the human keratinocyte cell line NCTC 2544.
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RF Safe Research Library
Jan 1, 2017
This in vitro study exposed human keratinocyte cells (NCTC 2544) to 50 Hz ELF-EMF at 0.25–2 G and assessed oxidative stress-related endpoints. Significant increases in ROS were reported at 0.5 and 1 G, with associated short-term changes in antioxidant and lipid peroxidation markers. The authors report that…
Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke Rehabilitation.
Research
RF Safe Research Library
Jan 1, 2017
This study assessed whether adding extremely low-frequency electromagnetic field (ELF-EMF) exposure to a 4-week poststroke rehabilitation program affects nitric oxide (NO)-related biomarkers and patient status. Forty-eight poststroke patients were assigned to ELF-EMF versus non-ELF-EMF rehabilitation, with the…
Cytotoxicity of temozolomide on human glioblastoma cells is enhanced by the concomitant exposure to an extremely low-frequency electromagnetic field (100Hz, 100G).
Research
RF Safe Research Library
Jan 1, 2017
This in vitro study tested whether an extremely low-frequency EMF (100 Hz, 100 G) could enhance temozolomide cytotoxicity in human glioma cell lines (U87 and T98G). The authors report that combined EMF and temozolomide increased apoptosis relative to either treatment alone and was accompanied by changes in…
Effect of electromagnetic fields and antioxidants on the trace element content of rat teeth.
Research
RF Safe Research Library
Jan 1, 2017
This animal study examined whether extremely low-frequency electromagnetic fields (ELF-EMFs) from a high-voltage source alter trace element concentrations in rat teeth and whether antioxidants (melatonin and glutathione) modify these changes. Rats were exposed 8 hours/day for 26 or 52 days, with separate sham…
Alterations of Immune Parameters on Trichoplusia ni (Lepidoptera: Noctuidae) Larvae Exposed to Extremely Low-Frequency Electromagnetic Fields.
Research
RF Safe Research Library
Jan 1, 2017
This animal study exposed Trichoplusia ni larvae to 60 Hz, 2.0 mT ELF-EMF for 24, 48, or 72 hours and assessed immune parameters and fertility. The abstract reports no effect on life cycle and fertility after 24 hours, but several immune-related measures changed after 48–72 hours, including reduced hemolymph protein…
Effects of extremely low-frequency electromagnetic fields (ELF-EMF) exposure on B6C3F1 mice
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RF Safe Research Library
May 5, 2015
This long-term animal study exposed mice to a 50 Hz magnetic field (500 mG) prenatally and then through 15.5 months of life to assess tumor-related outcomes and fertility-related measures. Exposed mice had lower body weights and showed no increase in liver or lung tumor incidence. However, exposed female mice had a…
The effects of different intensities, frequencies and exposure times of extremely low-frequency electromagnetic fields on the growth of Staphylococcus aureus and Escherichia coli O157:H7.
Research
RF Safe Research Library
Jan 1, 2015
This in vitro study examined whether extremely low-frequency electromagnetic fields (ELF-EMF) affect growth of Staphylococcus aureus and Escherichia coli O157:H7. Bacterial cultures were exposed to sinusoidal homogeneous ELF-EMF at 2 or 4 mT, with frequencies of 20, 40, or 50 Hz, for 1–6 hours, and CFU were compared…
Melatonin protects rat cerebellar granule cells against electromagnetic field-induced increases in Na(+) currents through intracellular Ca(2+) release
Research
RF Safe Research Library
Jan 1, 2014
This in vitro study examined extremely low-frequency electromagnetic field (ELF-EMF) effects on voltage-gated sodium (Nav) currents in rat cerebellar granule cells and whether melatonin modifies these effects. The abstract reports that 60 minutes of ELF-EMF exposure increased Nav current density, and that melatonin…
Exposure to extremely low-frequency electromagnetic fields inhibits T-type calcium channels via AA/LTE4 signaling pathway.
Research
RF Safe Research Library
Jan 1, 2014
This in vitro study examined 50 Hz ELF-EMF effects on human T-type calcium channels expressed in HEK293 cells and on native T-type channels in primary cultured mouse cortical neurons. The authors report that ELF-EMF (0.2 mT) inhibited Cav3.1, Cav3.2, and Cav3.3 channel activity without changing Cav3.2 expression or…
Proteomic analysis in human fibroblasts by continuous exposure to extremely low-frequency electromagnetic fields.
Research
RF Safe Research Library
Jan 1, 2007
This in vitro study examined whether continuous extremely low-frequency electromagnetic fields (3 Hz, 4 mT for 3 hours) alter protein expression in human fibroblast cells using proteomics. The authors report that some protein expressions differed between exposed and sham cells. They identify reduced expression (about…