Dose-dependent impact of extremely low-frequency electromagnetic field (ELF-EMF) on the neuroplasticity in the hippocampus of adult rats.
Research
RF Safe Research Library
Jan 1, 2026
This animal study examined whether 50 Hz ELF-EMF exposure at two intensities (1 mT vs 7 mT) alters hippocampal gene transcripts related to neuroplasticity and cell survival in adult rats across repeated exposure cycles. The authors report intensity- and exposure-number-dependent modulation of mRNA expression, with 1…
Effects of Simultaneous In-Vitro Exposure to 5G-Modulated 3.5 GHz and GSM-Modulated 1.8 GHz Radio-Frequency Electromagnetic Fields on Neuronal Network Electrical Activity and Cellular Stress in Skin Fibroblast Cells
Research
RF Safe Research Library
Jan 1, 2025
This in-vitro study exposed primary cortical neurons and human immortalized skin fibroblasts to simultaneous 5G-modulated 3.5 GHz and GSM-modulated 1.8 GHz RF-EMF at SARs of 1 or 4 W/kg. It reports no significant changes in neuronal network firing/bursting activity and no alteration of mitochondrial ROS in…
A Systematic Review of the Impact of Electromagnetic Waves on Living Beings
Research
RF Safe Research Library
Jan 1, 2025
This PRISMA-adherent systematic review searched PubMed, Scopus, and the Cochrane Library for studies (2017–2024) on physiological or behavioral responses to EMF exposure, emphasizing studies reporting harmful or concerning effects. Across 24 included studies (human non-randomized, in vitro, and animal), the review…
Possible effects of melatonin and omega-3 on the obesity-related hypothalamic nuclei of the electromagnetic field-exposed offspring rats: a stereological and immunohistochemical analysis.
Research
RF Safe Research Library
Jan 1, 2025
This animal study examined whether prenatal exposure to a 900 MHz electromagnetic field affects obesity-related hypothalamic nuclei in male rat offspring and whether melatonin or omega-3 modifies these effects. The EMF-exposed group showed fewer neurons in the arcuate nucleus, stronger NPY immunoreactivity, and…
The extremely low-frequency electromagnetic field (50 Hz) can establish a new "set-point" for the activity of the locus coeruleus-noradrenergic (LC-NA) system in rat.
Research
RF Safe Research Library
Jan 1, 2024
This animal study exposed rats to 50 Hz ELF-EMF at 1 mT or 7 mT for 1 hour/day over 7 days, repeated across three cycles, and assessed catecholamines, MHPG, β2-adrenergic receptor expression, and behavior. The authors report that ELF-EMF influences stress-response mechanisms involving the locus…
Impact of ketamine administration on chronic unpredictable stress-induced rat model of depression during extremely low-frequency electromagnetic field exposure: Behavioral, histological and molecular study.
Research
RF Safe Research Library
Jan 1, 2023
This animal study evaluated ketamine administration combined with extremely low-frequency electromagnetic field (ELF-EMF) exposure in a chronic unpredictable stress (CUS) rat model. The authors report that the combined treatment increased depression-like behavior and neuronal degeneration, reduced GFAP(+) cells in…
The Effect of Time-Dependence of 10 Hz Electromagnetic Field on Spatial Learning and Memory in Rats.
Research
RF Safe Research Library
Jan 1, 2022
This animal study exposed 40 adult male rats to a 10 Hz (4 mT) extremely low-frequency electromagnetic field for 1 hour daily for either 7 or 30 days. The authors report improved spatial memory after prolonged (30-day) exposure, alongside increased hippocampal BDNF levels. They also note a significant body weight…
Evaluation of the neuroprotective effects of electromagnetic fields and coenzyme Q on hippocampal injury in mouse.
Research
RF Safe Research Library
Jan 1, 2019
This animal study tested whether 50 Hz EMF exposure and/or CoQ10 could protect against TMT-induced hippocampal injury in mature female mice. CoQ10 and CoQ10+EMF were associated with improved spatial memory and reduced histological markers of cell death, alongside increased antiapoptotic markers. EMF alone reportedly…
Decreased dopamine in striatum and difficult locomotor recovery from MPTP insult after exposure to radiofrequency electromagnetic fields.
Research
RF Safe Research Library
Jan 1, 2019
This animal study reports that chronic RF-EMF exposure (835 MHz, SAR 4.0 W/kg, 5 h/day for 12 weeks) affected striatal neuronal markers in C57BL/6 mice. The authors observed reductions in synaptic vesicle-related measures and dopaminergic markers, including dopamine concentration and tyrosine hydroxylase expression.…
Acute exposure to high-induction electromagnetic field affects activity of model peripheral sensory neurons.
Research
RF Safe Research Library
Jan 1, 2018
This in vitro study examined acute low-frequency electromagnetic field (LF-EMF) exposure using high-induction magnetic stimulation in F11 cells, a dorsal root ganglia neuron-derived model of peripheral sensory neurons. Short-term exposure (
Non-conductive and miniature fiber-optic imaging system for real-time detection of neuronal activity in time-varying electromagnetic fields.
Research
RF Safe Research Library
Jan 1, 2017
This paper describes a non-conductive, miniature fiber-optic imaging system designed to record neuronal activity in real time during repetitive, long-term time-varying EMF exposure. Using the system, the authors report that short exposures (
Protective effects of melatonin and omega-3 on the hippocampus and the cerebellum of adult Wistar albino rats exposed to electromagnetic fields.
Research
RF Safe Research Library
Jan 1, 2017
This rat study examined 900 MHz EMF exposure for 60 minutes per day over 15 days and assessed hippocampal and cerebellar outcomes, behavior, and serum enzyme activity. The EMF-only group showed significant neuronal cell losses in multiple brain regions and worse passive avoidance performance compared with other…
Melatonin protects rat cerebellar granule cells against electromagnetic field-induced increases in Na(+) currents through intracellular Ca(2+) release
Research
RF Safe Research Library
Jan 1, 2014
This in vitro study examined extremely low-frequency electromagnetic field (ELF-EMF) effects on voltage-gated sodium (Nav) currents in rat cerebellar granule cells and whether melatonin modifies these effects. The abstract reports that 60 minutes of ELF-EMF exposure increased Nav current density, and that melatonin…
No influence of acute RF exposure (GSM-900, GSM-1800, and UMTS) on mouse retinal ganglion cell responses under constant temperature conditions.
Research
RF Safe Research Library
Jan 1, 2014
This double-blind in vitro study exposed isolated mouse retinae to GSM-900, GSM-1800, and UMTS RF-EMF at SARs up to 20 W/kg while maintaining constant temperature. Changes in retinal ganglion cell responses to light stimuli were compared before, during, and up to 35 minutes after exposure. The authors report no…
[Influence of electromagnetic radiation on raf kinase inhibitor protein and its related proteins of hippocampus].
Research
RF Safe Research Library
Jan 1, 2008
This rat study examined hippocampal RKIP and related markers after exposure to high power microwaves (X-band and S-band) or an electromagnetic pulse. RKIP protein decreased at 6 hours post-exposure, with recovery by 1 day in the EMP group but more prolonged decreases (up to ~7 days) in the microwave groups.…