Different profiles of the mRNA levels of DNA repair genes in MCF-7 and SH-SY5Y cells after treatment with combination of cisplatin, 50-Hz electromagnetic field and bleomycin.
Research
RF Safe Research Library
Jan 1, 2017
This in vitro study examined whether a 50-Hz, 0.50 mT intermittent electromagnetic field modifies responses to cisplatin and bleomycin in MCF-7 and SH-SY5Y cells. The authors report increased susceptibility in MCF-7 cells with EMF added to cisplatin+bleomycin, while SH-SY5Y susceptibility was unchanged. They also…
Cytotoxicity of temozolomide on human glioblastoma cells is enhanced by the concomitant exposure to an extremely low-frequency electromagnetic field (100Hz, 100G).
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RF Safe Research Library
Jan 1, 2017
This in vitro study tested whether an extremely low-frequency EMF (100 Hz, 100 G) could enhance temozolomide cytotoxicity in human glioma cell lines (U87 and T98G). The authors report that combined EMF and temozolomide increased apoptosis relative to either treatment alone and was accompanied by changes in…
Precision knockdown of EGFR gene expression using radio frequency electromagnetic energy.
Research
RF Safe Research Library
Jan 1, 2017
This study reports a technology that records a specific radiofrequency electromagnetic energy signal associated with EGFR siRNA and applies it to cells. The abstract describes reductions in EGFR mRNA and protein expression versus controls, with specificity assessed using RNA microarray and antibody dot blot array. It…
Enhancement of osteogenic differentiation of rat adipose tissue-derived mesenchymal stem cells by zinc sulphate under electromagnetic field via the PKA, ERK1/2 and Wnt/β-catenin signaling pathways.
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RF Safe Research Library
Jan 1, 2017
This in vitro study examined rat adipose-derived mesenchymal stem cells exposed to zinc sulphate in the presence of an ELF electromagnetic field (50 Hz, 20 mT). The authors report increased osteogenic differentiation markers (gene expression, ALP activity, and calcium levels) under combined ZnSO4+EMF conditions,…
Quantum mechanical model for the anticarcinogenic effect of extremely-low-frequency electromagnetic fields on early chemical hepatocarcinogenesis.
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RF Safe Research Library
Jan 1, 2017
This study develops a quantum-mechanical radical pair mechanism model to examine how an extremely-low-frequency electromagnetic field (ELF-EMF) might influence early chemical hepatocarcinogenesis in rats. The model evaluates singlet-state recombination and quantum yield under a low magnetic field effect, proposing…
Calreticulin attenuated microwave radiation-induced human microvascular endothelial cell injury through promoting actin acetylation and polymerization.
Research
RF Safe Research Library
Jan 1, 2017
This in vitro study exposed human microvascular endothelial cells to high-power microwave radiation at multiple power densities for 6 minutes and assessed cellular injury and cytoskeletal outcomes. The authors report dose-dependent injury from microwave exposure, including increased LDH leakage and reduced viability…
Epitaxy of the bound water phase on hydrophilic surfaces of biopolymers as key mechanism of microwave radiation effects on living objects.
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RF Safe Research Library
Jan 1, 2017
This study examined proposed mechanisms of microwave radiation effects using a bacterial culture and a sterile growth medium, focusing on a sensor bioluminescence system. The authors report irradiation-related changes in UV spectral properties (200–350 nm), luminescence, NMR relaxation parameters, bacterial growth,…
A Route to Chaotic Behavior of Single Neuron Exposed to External Electromagnetic Radiation.
Research
RF Safe Research Library
Jan 1, 2017
This computational study investigates nonlinear membrane-potential dynamics in a Fitzhugh-Nagumo single-neuron model that includes an external electromagnetic radiation term. The authors report that increasing the frequency of an external transmembrane current leads to mode selection among periodic, quasi-periodic,…
Electromagnetic Fields Act Similarly in Plants as in Animals: Probable Activation of Calcium Channels via Their Voltage Sensor
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RF Safe Research Library
Jan 1, 2016
This narrative review proposes that low-intensity microwave/lower-frequency EMFs activate plasma membrane calcium channels in animals, increasing intracellular calcium and triggering downstream signaling including oxidative stress pathways. It further suggests that EMF actions in terrestrial multicellular plants are…
Microwave frequency electromagnetic fields (EMFs) produce widespread neuropsychiatric effects including depression
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RF Safe Research Library
Jan 1, 2016
This 2016 narrative review proposes that non-thermal microwave/lower-frequency EMFs act primarily through activation of voltage-gated calcium channels (VGCCs), with calcium channel blockers reported to block EMF effects. It summarizes animal, occupational, and epidemiological literature and reports that exposures…
Targeted Magnetic Nanoparticles for Mechanical Lysis of Tumor Cells by Low-Amplitude Alternating Magnetic Field.
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RF Safe Research Library
Jan 1, 2016
This animal and in vitro study reports a method to lyse tumor cells mechanically using targeted superparamagnetic iron oxide nanoparticles rotated by a weak alternating magnetic field. Nude mice with head and neck tumors received cetuximab-coated nanoparticles and 4 Hz field exposures for 30 minutes on alternating…
Investigation of Electric Field-Induced Structural Changes at Fe-Doped SrTiO₃ Anode Interfaces by Second Harmonic Generation.
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RF Safe Research Library
Jan 1, 2016
This materials study used optical second harmonic generation to detect electric field-induced structural changes at Pt/Fe-doped SrTiO3 anode interfaces. Reduced crystals showed steadily increasing susceptibility with increasing negative voltage, interpreted as electrostriction-related bond distortions. Oxidized…
[The influence of alternating magnetic field on in vitro litholysis of uroliths in blemaren water solutions].
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RF Safe Research Library
Jan 1, 2016
This in vitro study examined whether exposing Blemaren water solutions (pH 6.15) to a 2 Hz alternating magnetic field for one hour changes their ability to dissolve uroliths. The authors report higher dissolution efficiency (about 1.922d7) in pre-exposed solutions compared with non-exposed controls. They also report…
[Genic and non-genic regulation of low frequence pulsed electromagnetic fields on osteoblasts differentiation].
Research
RF Safe Research Library
Jan 1, 2016
This in vitro study exposed rat calvarial osteoblasts to 50 Hz, 0.6 mT pulsed electromagnetic fields for 1.5 hours and measured early differentiation-related markers over 0–12 hours. The abstract reports increased ALP activity at 3 hours and time-dependent changes in ALP, Runx2, and OSX transcription and Runx2/OSX…
Disordered redox metabolism of brain cells in rats exposed to low doses of ionizing radiation or UHF electromagnetic radiation.
Research
RF Safe Research Library
Jan 1, 2016
This animal study assessed redox-state changes in rat brain cells after long-term low-intensity ionizing radiation exposure or fractionated non-thermal UHF electromagnetic radiation. Both exposures were associated with decreased ubisemiquinone and increased NO-FeS-protein complexes, alongside increased mitochondrial…
Exposure to 900 MHz electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats
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RF Safe Research Library
Mar 19, 2015
This animal study exposed 108 male Sprague-Dawley rats to 900 MHz EMF (1 mW/cm2) or sham for 14 or 28 days (3 h/day). The authors report that 28-day exposure was associated with impaired spatial memory, BBB permeability damage, and ultrastructural changes in hippocampus and cortex. They also report increased mkp-1…
Effects of microwave radiation on brain energy metabolism and related mechanisms
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RF Safe Research Library
Feb 17, 2015
This paper is a narrative review of microwave radiation and brain energy metabolism. The abstract frames the brain as a sensitive target organ and highlights mitochondrial injury and energy metabolism disorders as important in microwave radiation-induced brain damage. It aims to summarize biological effects, brain…
Low-Frequency Electromagnetic Field Exposure Enhances Extracellular Trap Formation by Human Neutrophils through the NADPH Pathway
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RF Safe Research Library
Jan 1, 2015
This in vitro/ex vivo study examined whether low-frequency electromagnetic field exposure affects human neutrophil extracellular trap (NET) formation. The authors report that LF EMF exposure enhanced NET formation and that this effect depended on the NADPH oxidase pathway and reactive oxygen species production. They…
[Modulation of Ca(2+)-Dependent Proteiolysis under the Action of Weak Low-Frequency Magnetic Fields].
Research
RF Safe Research Library
Jan 1, 2015
This animal/model-organism study examined whether weak low-frequency magnetic fields tuned to a proposed parametric resonance for calcium ions affect Ca(2+)-dependent proteolysis. It reports time-dependent modulation of Ca(2+)-dependent proteinase activity in fish and whelk and states that a minimal exposure time for…
Data supporting the role of electric field and electrode material on the improvement of the ageing effects in hydrogenated amorphous silicon solar cells.
Research
RF Safe Research Library
Jan 1, 2015
This Data in Brief article provides additional experimental data supporting a related study on mitigating ageing effects (Staebler-Wronski effect) in hydrogenated amorphous silicon solar cells. The associated method involves applying reverse bias stress and evaluating how temperature, electric field intensity,…
[Influence of Low-Frequency Electromagnetic Field on DNA Molecules in Water Solutions].
Research
RF Safe Research Library
Jan 1, 2015
This in vitro study reports that hepatitis B and C virus DNA amplicons in water solutions produced a chemiluminescence-registered signal after exposure to low-frequency electromagnetic fields (3–30 Hz; 24–40 A/m). The strongest reported effect occurred at 9 Hz, alongside an observed change in the DNA hydration shell.…
Electromagnetic fields (UHF) increase voltage sensitivity of membrane ion channels; possible indication of cell phone effect on living cells.
Research
RF Safe Research Library
Jan 1, 2015
This in vitro study used voltage clamp recordings of single OmpF porin channels in an artificial bilayer to test effects of UHF EMF (910–990 MHz). The authors report frequency-dependent changes in channel gating, with increased gating frequency and voltage sensitivity and a maximum effect at 930 MHz. Conductance was…
Experimental model for ELF-EMF exposure: Concern for human health.
Research
RF Safe Research Library
Jan 1, 2015
This in vitro study examined whether extremely low frequency EMF exposure alters MCP-1 expression in several human cell lines. Cells were exposed to a 50 Hz sinusoidal field at 1 mT (rms), and the authors report that MCP-1 expression was modified in a cell-type-dependent manner. The findings are described as…
Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats
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RF Safe Research Library
Jan 1, 2014
This animal study examined 2.45 GHz Wi-Fi exposure in a PTZ-induced epilepsy rat model using freshly isolated hippocampal and DRG neurons. The authors report that epilepsy increased Ca(2+) influx, oxidative stress markers, and apoptosis-related outcomes, and that Wi-Fi exposure produced additional increases in…
Melatonin protects rat cerebellar granule cells against electromagnetic field-induced increases in Na(+) currents through intracellular Ca(2+) release
Research
RF Safe Research Library
Jan 1, 2014
This in vitro study examined extremely low-frequency electromagnetic field (ELF-EMF) effects on voltage-gated sodium (Nav) currents in rat cerebellar granule cells and whether melatonin modifies these effects. The abstract reports that 60 minutes of ELF-EMF exposure increased Nav current density, and that melatonin…