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Trends in Malignant and Benign Brain Tumor Incidence and Mobile Phone Use in the U.S. (2000-2021): A SEER-Based Study

Research RF Safe Research Library Jan 1, 2025

This SEER-based ecological study examined U.S. trends (2000–2021) in malignant and benign brain tumor incidence and compared them with national mobile phone subscription trends. Malignant brain tumor incidence in adolescents and adults declined slightly, while benign brain tumor incidence increased over time; temporal lobe tumors and benign acoustic neuromas showed little change. The authors interpret these patterns as not supporting an association between mobile phone use and increased brain cancer risk, while recommending continued surveillance given rising benign tumor incidence and potential latency.

The proliferation rates of HT-1080 human fibrosarcoma cells can be accelerated or inhibited by weak static and extremely low frequency magnetic fields

Research RF Safe Research Library Jan 1, 2025

This in vitro study exposed HT-1080 human fibrosarcoma cells for 4 days to weak extremely low frequency magnetic fields (10 μT, 12–33 Hz) superimposed on a 45 μT static field. The authors report frequency- and amplitude-dependent increases or decreases in cell growth, including sharp inversions near 16.5 Hz with small parameter changes or reversal of the static field direction. Associated changes in membrane potential, intracellular calcium, and mitochondrial superoxide are presented as supporting a bioenergetic mechanism.

A comprehensive mechanism of biological and health effects of anthropogenic extremely low frequency and wireless communication electromagnetic fields

Research RF Safe Research Library Jan 1, 2025

This narrative review discusses biological mechanisms and reported health effects of anthropogenic extremely low frequency (ELF) and wireless communication (WC) electromagnetic fields. It highlights oxidative stress and DNA damage as key mechanistic endpoints and proposes an IFO-VGIC pathway linking EMF exposure to ROS overproduction and cellular dysfunction. The authors interpret the broader literature as indicating risks (e.g., cancer, infertility, EHS) even below current exposure limits and advocate precautionary policy measures, including stricter limits and a 5G moratorium.

Carcinogenicity of extremely low-frequency magnetic fields: A systematic review of animal studies

Research RF Safe Research Library Jan 1, 2025

This PRISMA-based systematic review evaluated 54 animal studies on the carcinogenicity of extremely low-frequency (ELF) magnetic fields. The authors report very little evidence that ELF magnetic fields alone are carcinogenic. Findings on co-carcinogenicity (ELF MFs combined with other agents) are inconclusive, and the review notes a clear indication of publication bias.

Effects of radiofrequency electromagnetic field exposure on cancer in laboratory animal studies, a systematic review

Research RF Safe Research Library Jan 1, 2025

This systematic review evaluated RF EMF exposure and cancer outcomes in experimental animals, including chronic cancer bioassays and tumor-promotion designs. Across 52 included studies, the authors report high certainty of evidence for increased malignant heart schwannomas and gliomas in male rats, and moderate certainty for increased risks of several other tumor types. Many other organ systems showed no or minimal evidence of carcinogenic effects, and the authors note challenges in translating animal findings to human risk assessment due to exposure and mechanistic uncertainties.

Residential exposure to magnetic field due to high-voltage power lines and childhood leukemia risk in mainland France - GEOCAP case-control study

Research RF Safe Research Library Jan 1, 2025

This French GEOCAP registry-based case-control study evaluated childhood acute leukemia risk in relation to residential proximity to high-voltage overhead power lines and modeled ELF magnetic-field exposure. It reports an increased risk for children under 5 living within 50 m of power lines, particularly when restricting to high-quality geocoded addresses. However, modeled ELF-MF exposure >0.3 µT was not associated with increased risk, and the authors suggest proximity may capture other factors and call for further research and precaution.

Use of Mobile and Cordless Phones and the Association with Prostate Cancer

Research RF Safe Research Library Jan 1, 2025

This pooled analysis of two prior human studies reports increased odds of prostate cancer associated with mobile phone use, with higher estimates for longer latency and higher cumulative hours. Cordless phone use is reported to show increased risk but not statistically significant overall, with one mid-range cumulative use category showing an elevated OR. The abstract also reports higher risks among men with more aggressive prostate cancer and among those with a family history of prostate cancer.

Magneto-oncology: a radical pair primer

Research RF Safe Research Library Jan 1, 2025

This mini-review discusses the radical pair mechanism as a plausible biophysical route by which external magnetic fields could influence biochemical processes in living systems. It is intended as a primer for magneto-oncology researchers to assess whether observed magnetic-field-related biomedical effects may be explained by radical pair biochemistry. The article also notes the value of this framework for refining therapeutic protocols and for identifying potential experimental artifacts in oncology-related magnetic field research.

Is Cellphone Carrying Below the Waist (Exposure to Non-Ionizing Radiation) Contributing to the Rapid Rise in Early-Onset Colorectal Cancer?

Research RF Safe Research Library Jan 1, 2024

This conference abstract reports a pilot matched case-control study examining whether carrying a cellphone below the waist is associated with early-onset colorectal cancer (EOCRC). The authors report higher EOCRC likelihood among those who carried phones below the waist, with the strongest association for ipsilateral carrying (same side as the tumor) and high cumulative hours. Details on exposure measurement, confounding control, and full statistical reporting are not provided in the abstract.

The Systematic Review on RF-EMF Exposure and Cancer by Karipidis et al. (2024) has Serious Flaws that Undermine the Validity of the Study's Conclusions

Research RF Safe Research Library Jan 1, 2024

This letter critiques the WHO-sponsored systematic review by Karipidis et al. (2024) on RF-EMF exposure and cancer risk. The authors argue the review has serious methodological and interpretative flaws, including issues with study selection and data analysis. They contend that the review’s conclusion of "no clear evidence" may be misleading and should not be used as a basis for health policy or safety guidelines.

Relationship between radiofrequency-electromagnetic radiation from cellular phones and brain tumor: meta-analyses using various proxies for RF-EMR exposure-outcome assessment

Research RF Safe Research Library Jan 1, 2024

Moon et al. (2024) report a systematic review and meta-analysis on cellular phone RF-EMR and brain tumor risk. The abstract summary states elevated risks for three brain tumor types in analyses considering ipsilateral (same-side) phone use and reports increased risk with heavy and long-term use. The text also highlights disagreement with the 2024 WHO review and raises methodological concerns about WHO conclusions.

Toxicology and carcinogenesis studies in Sprague Dawley (Hsd:Sprague Dawley SD) rats exposed to whole-body radio frequency radiation at a frequency (900 MHz) and modulations (GSM and CDMA) used by cell phones

Research RF Safe Research Library Jan 1, 2018

This National Toxicology Program technical report describes 900 MHz whole-body RFR exposures (GSM and CDMA) in male and female Sprague Dawley rats from in utero through up to 2 years. The report concludes clear evidence of carcinogenic activity in males for both modulations based on malignant schwannoma of the heart, with malignant glioma of the brain also reported as related to exposure. In females, the report concludes equivocal evidence of carcinogenic activity for both modulations based on selected tumor outcomes, and genetic toxicology findings were mixed with some comet assay increases/equivocal results but negative micronucleus assays.

Cell phones and brain tumors: a review including the long-term epidemiologic data

Research RF Safe Research Library Jan 1, 2009

This paper presents a meta-analysis of 11 peer-reviewed epidemiologic studies examining long-term (>=10 years) cell phone use with laterality analyses. It reports that long-term use is associated with an approximately doubled risk of an ipsilateral brain tumor. The abstract states statistical significance for glioma and acoustic neuroma, but not for meningioma.

Mobile phone use and cancer

Research RF Safe Research Library Jan 1, 2004

This narrative review discusses potential public health consequences of widespread mobile phone use and the controversy around long-term cancer risks. It states that evidence from epidemiological and experimental studies suggests long-term exposure to mobile phone emissions may be linked to a small to moderate increased risk of certain cancers, while also emphasizing that data are insufficient for a final risk assessment. The author argues that even small risks could matter at the population level and that exposure-reduction measures may be indicated given uncertainties.

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