HHS-OASH-2026-0397-5812 https://www.regulations.gov/comment/HHS-OASH-2026-0397-5812 Aires response to HHS RFI HHS-OASH-2026-0397 For more than three decades, the Aires research program has pursued one enduring objective: to engineer electromagnetic environments that support biological function. Its documented history extends to 1992, connecting early patterned materials and optical filters with successive silicon resonators and biological investigations. The attached response presents this connected research lineage. The primary record identifies more than 50 named authors and researchers, 15 academic, medical and research institutions represented through testing sites or author affiliations, and contributions from Russia, Lithuania and Canada. The archive review encompassed 97 research-related records, including translations, related versions and background materials. The response organizes its research and contextual sources into 44 reference entries; related publications of one experiment are identified as a research family. The breadth is central to our contribution: human EEG, ECG and heart-rate variability; human erythrocytes tested outside the body for osmotic response using laser diffraction; chromosome abnormalities in rat bone-marrow cells; rat behavior, learning, memory and blood parameters; honeybee feeding, memory and brain hsp70 gene expression; and goldfish movement. Water conductivity and infrared investigations, liquid crystals, thin films, patterned silicon, direct RF measurements and electromagnetic models supply the complementary physical research. To evaluate an intervention, researchers also investigated the exposure response itself. Mobile-phone and Wi-Fi protocols therefore contribute evidence about biological responses under specified exposures and about what changes when an Aires device is introduced. Repeated rat bone-marrow investigations reported increased chromosome abnormalities with router exposure and reductions with resonators. Other studies examine physiological regulation, susceptibility, recovery, behavior and molecular response in their respective biological settings. More than two decades of EEG and HRV investigations connect early patterned-material and optical-filter work with later phone-exposure protocols and personal-device studies. Across this sequence, investigators examined baseline state, brain activity, autonomic regulation and recovery. The response presents this human research as a connected program, with study-specific comparisons and findings retained in Appendix B. The response addresses Questions 2, 4, 5(n)-(p), 7-18, with the full research story under Questions 4 and 18. Question 12 discusses assessment against federal exposure limits without assuming that every experiment supplies the same dosimetric information. Traceable publications include the 2019 Ecological Genetics rat bone-marrow study (DOI 10.17816/ecogen17283-92), the 2020 Integrative Physiology honeybee study (DOI 10.33910/2687-1270-2020-1-3-231-241), the 2018 Lithuanian conference investigation of gigahertz fields, and Springer ICICT proceedings on semiconductor modeling (DOI 10.1007/978-981-19-1607-6_7) and 2026 thermal characterization (DOI 10.1007/978-3-032-28964-3_5). The attachment contains 44 references identifying journal articles, conference publications, technical reports and other source types. We request a technical briefing with the HHS team responsible for this RFI and relevant scientific staff at FDA, NIH and CDC to examine the research lineage, review exposure-and-intervention protocols, and identify coordinated physical and biological investigations. We ask HHS to include engineered electromagnetic environments and field-modulation technologies in its research priorities, including evaluation in personal device use, occupied spaces and equipment integration. Aires brings an accumulated experimental record and practical experience developing successive technology generations. We invite HHS to engage with us on how that record can inform its assessment of RF/EMF exposure and its next research priorities. For follow-up and a technical briefing: Josh Bruni, CEO, Aires, josh@airestech.com. Public evidence index: https://airestech.com/pages/hhs-emf-evidence-2026