HHS-OASH-2026-0397-4409 https://www.regulations.gov/comment/HHS-OASH-2026-0397-4409 **Re: HHS-OASH-2026-0397 — RF/EMF Exposure, Reproductive Health, Mitochondrial Function, and Emerging Wireless Technologies** **Questions 2–3: Personal Perspective** I am a 43-year-old woman experiencing unexplained infertility. For more than half my life, I have lived in metropolitan environments with extensive cellular infrastructure, Wi-Fi networks, and wireless devices. Although I cannot establish that these exposures contributed to my infertility, I question whether the long-term biological consequences of widespread RF exposure have been adequately investigated, particularly regarding reproductive health, mitochondrial function, and developing children. **Questions 5, 6, and 11–12: Reproductive and Mitochondrial Health** I urge HHS to examine whether current RF exposure standards adequately address reproductive and developmental outcomes, including potential biological effects beyond tissue heating. A 2024 systematic review by Cordelli et al. identified potential adverse reproductive effects in experimental studies, although evidence remains uncertain. A 2024 review by Meyer et al. examined oxidative-stress biomarkers and found very low-certainty evidence. Mitochondrial function is fundamental to cellular energy production, fertility, and healthy development. I request independent studies investigating whether chronic RF exposure influences mitochondrial respiration, oxidative stress, egg and sperm quality, implantation, pregnancy outcomes, or childhood development. Research should prioritize women attempting conception, pregnant women, developing fetuses, and children, using objective measurements of real-world, cumulative exposure. **Question 13: 5G and Emerging 6G Technologies** Emerging 6G systems may use higher-frequency spectrum, including sub-terahertz frequencies, to support greater bandwidth and data capacity. Advanced beamforming and denser wireless infrastructure may also alter exposure patterns. Although higher frequency alone does not establish greater biological harm, expanding these technologies without adequate long-term biological research raises legitimate public health questions. I urge HHS to independently evaluate the biological implications of emerging frequencies and exposure patterns before widespread deployment wherever feasible, rather than assuming existing standards adequately address every new technology. **Questions 14–15: Environmental Health** Potential RF effects on pollinators, birds, plants, and other organisms also warrant investigation, particularly concerning reproduction, development, behavior, and ecosystem health. **Questions 9, 16–17: Federal Research Priorities** I respectfully request that HHS: 1. Fund independent, longitudinal studies examining fertility, pregnancy, childhood development, and mitochondrial function. 2. Investigate biological endpoints beyond tissue heating, including oxidative stress and cellular energy metabolism. 3. Measure realistic, cumulative exposure from multiple wireless sources, accounting for frequency, intensity, duration, and proximity. 4. Establish transparent research priorities for 5G and 6G, with independent replication and disclosure of funding conflicts. 5. Provide accessible exposure data and evidence-based guidance to families seeking to minimize unnecessary exposure. **Conclusion** Technological advancement should be accompanied by equally rigorous public health research and accountability. As a woman struggling to conceive, I believe reproductive health, mitochondrial integrity, and the biological consequences of lifelong environmental exposure deserve serious federal attention. Scientific uncertainty should motivate independent investigation, transparent risk assessment, and reasonable precaution—not premature assurances of safety or unsupported claims of harm. **Selected References** Cordelli et al. (2024). *Environment International*, 185, 108509. https://doi.org/10.1016/j.envint.2024.108509 Meyer et al. (2024). *Environment International*, 194, 108940. https://doi.org/10.1016/j.envint.2024.108940