{"id":"HHS-OASH-2026-0397-1956","number":"1956","name":"P G","organization":"","posted":"2026-10-09T04:00Z","received":"2026-10-08T04:00Z","body":"See attached file(s)\n\nA Narrative Review on the Influence of Electromagnetic Fields\nBelow 100 kHz on the Endocrine System\n2026\n\nAbstract\nBackground: Extremely low-frequency electromagnetic fields (ELF-EMFs), generated\nmainly by power infrastructure and household devices, have raised scientific interest\ndue to their potential impact on the endocrine system. Animal research consistently shows\neffects on melatonin secretion, stress hormone levels, thyroid activity, and reproductive\nfunction—largely mediated by oxidative stress and calcium ion imbalance. In contrast,\nhuman studies remain inconsistent, often hindered by methodological limitations and\ninsufficient exposure characterization. Objective: This review synthesizes experimental\nand epidemiological studies examining low-frequency electromagnetic field exposure\n(≤100 kHz) and its influence on hormonal regulation. Methods: A bibliometric analysis\nhighlights focused interest on specific endocrine targets, particularly the pineal gland.\nImportantly, many experimental studies use field strengths above those found near high-\nvoltage power lines, limiting direct applicability. Conclusions: While a definitive causal\nlink has not been established, the widespread exposure to low-frequency electromagnetic\nfields justifies precautionary considerations. Several important research gaps remain, many\nof which are identified in this review. The topic of low-frequency electromagnetic field\neffects on the endocrine system requires more rigorous, long-term human studies with\naccurate exposure assessment.\n\nKeywords: electromagnetic field; endocrine system; hormones; cancer; EMF exposure","attachments":["https://downloads.regulations.gov/HHS-OASH-2026-0397-1956/attachment_1.pdf"],"attachment_inventory":true,"withheld":false,"source":"https://www.regulations.gov/comment/HHS-OASH-2026-0397-1956","tags":["cancer-tumors","biology-metabolism","policy-standards","research-evidence"],"source_hash":"26406bf5c61f63a747fdcb7b134930b25296a27082a9dd290a6c0d821201bfba","slug":"cancer-tumors-comment-1956","classification":{"id":"HHS-OASH-2026-0397-1956","body_sha256":"08ee901603adf770a8be4f251b72ef5a8b54d26c65db8538c047757f757237ac","status":"ai_reviewed","primary_topic":"research","topics":[{"id":"research","evidence":"ress and calcium ion imbalance. In contrast,\nhuman studies remain inconsistent, often hindered by methodological limitations and\ninsu"},{"id":"mechanisms","evidence":"nd reproductive\nfunction—largely mediated by oxidative stress and calcium ion imbalance. In contrast,\nhuman studies "},{"id":"reproductive","evidence":"stress hormone levels, thyroid activity, and reproductive\nfunction—largely mediated by oxidative stress and calc"},{"id":"electricity","evidence":"netic fields (ELF-EMFs), generated\nmainly by power infrastructure and household devices, have raised scientific interest"},{"id":"other","evidence":"nterest\ndue to their potential impact on the endocrine system. Animal research consistently shows\neffects on "}],"summary":"Provides a review abstract describing experimental endocrine effects, inconsistent human findings and limits of exposure extrapolation, and calling for rigorous long-term human research.","reviewed_at":"2026-10-10T00:02:05Z","review_method":"Complete published comment-body review; identical previously reviewed bodies reused with separate official IDs preserved. Attachments and external links not reviewed.","review_source_sha256":"2a3eec1d5b322a24aaf2199deef220f55ddff001294903188a811e9fb178ec9f","source_url":"https://rfsafe.net/hhs-comments/data/catalog.json","scope":"Original comment body; attachments excluded"},"forum_topics":["research","mechanisms","reproductive","electricity","other"],"primary_topic":"research","forum_title":"Provides a review abstract describing experimental endocrine effects, inconsistent human findings and lim…"}