{"id":"HHS-OASH-2026-0397-2539","number":"2539","name":"Tia Pearson","organization":"","posted":"2026-10-13T04:00Z","received":"2026-10-10T04:00Z","body":"http://www.ncbi.nlm.nih.gov/pubmed/32395207  Objectives: Exposure to electromagnetic fields (EMF) emitted from mobile phones may cause a deleterious effect on human health and may affect the male reproductive system., a carotenoid isolated from, is a phar¬macologically active component of saffron. So, this study was conducted to investigate the protective effect ofon the male reproductive system of 60 day old mice after EMF exposure.\nMaterials and Methods: Twenty-four male BALB/c mice were randomly divided into 4 groups: 1. Em group (2100 MHZ); 2. Cr group (50 mg/kg); 3. Em+Cr group (2100 MHZ+50 mg/kg), and 4. Control group. Sperm parameters (count, and abnormal percent), testis weight index, testis volume, seminiferous tubule diam¬eter, germinal epithelium thickness, LH, FSH and testosterone serum level, testicular Heat shock protein A2 (HspA2) immunoreactivity, and apoptosis were evaluated.\nResults: HspA2 immunoreactivity, apoptosis in the germinal epithelium and abnormal sperm were increased in Em group compared with the control group","attachments":[],"attachment_inventory":true,"withheld":false,"source":"https://www.regulations.gov/comment/HHS-OASH-2026-0397-2539","tags":["biology-metabolism","research-evidence"],"source_hash":"b17f1718561ce63d58804e2565532a49faf671f5eae922bc4fcb53fe55c1f522","slug":"biology-metabolism-comment-2539","classification":{"id":"HHS-OASH-2026-0397-2539","body_sha256":"7e48e8ed0b47c7a43ce7c0110e8a2c7932ed25b7af146036042bcaef5a6eb8aa","status":"ai_reviewed","primary_topic":"reproductive","topics":[{"id":"reproductive","evidence":"in the germinal epithelium and abnormal sperm were increased in Em group compared with the control group"},{"id":"research","evidence":"y active component of saffron. So, this study was conducted to investigate the protective effect ofon the"},{"id":"mechanisms","evidence":"rotein A2 (HspA2) immunoreactivity, and apoptosis were evaluated.\nResults: HspA2 immunoreactivity, apoptosis "}],"summary":"Provides an abstract excerpt from a mouse study of RF exposure and a saffron-derived compound, describing reproductive endpoints and reported changes in sperm and testicular tissue.","reviewed_at":"2026-10-14T13:55:48Z","review_method":"Source-based AI review of complete published comment bodies; exact evidence passages; attachments and external links not reviewed.","review_source_sha256":"0a1a5b06a8f1ee683cd39c36ed4f28c30bea3137f338eeebad7413dc8425adef","source_url":"https://rfsafe.net/hhs-comments/data/catalog.json","scope":"Original comment body; attachments excluded"},"forum_topics":["reproductive","research","mechanisms"],"primary_topic":"reproductive","forum_title":"Provides an abstract excerpt from a mouse study of RF exposure and a saffron-derived compound, describing…"}